The ISG15-Protease USP18 Is a Pleiotropic Enhancer of HIV-1 Replication
Chaohui Lin,
Edmund Osei Kuffour,
Taolan Li
et al.
Abstract:The innate immune response to viruses is formed in part by interferon (IFN)-induced restriction factors, including ISG15, p21, and SAMHD1. IFN production can be blocked by the ISG15-specific protease USP18. HIV-1 has evolved to circumvent host immune surveillance. This mechanism might involve USP18. In our recent studies, we demonstrate that HIV-1 infection induces USP18, which dramatically enhances HIV-1 replication by abrogating the antiviral function of p21. USP18 downregulates p21 by accumulating misfolded… Show more
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