The isolation of the Amaryllidaceae alkaloid crinamine from Dioscorea dregeana (Dioscoreaceae)

Mulholland, Dulcie A.; Crouch, Neil R.; Decker, Bronwen; Smith, M.T.

doi:10.1016/s0305-1978(01)00072-2

Cited by 16 publications

(9 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although benzylphenethylamine alkaloids were considered to belong exclusively to the Amaryllidaceae, some of them have been found to belong to other families [35]. A new example of this exception was found through the chemical investigation of Hosta plantaginea (Liliaceae) [36].…”

Section: Alkaloids With Ache Inhibitory Activitymentioning

confidence: 99%

Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy

et al. 2013

View full text Add to dashboard Cite

As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer’s disease, efforts are being made in search of new molecules with anti-AChE activity. The fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery of an important number of secondary metabolites and plant extracts with the ability of inhibiting the enzyme AChE, which, according to the cholinergic hypothesis, increases the levels of the neurotransmitter acetylcholine in the brain, thus improving cholinergic functions in patients with Alzheimer’s disease and alleviating the symptoms of this neurological disorder. This review summarizes a total of 128 studies which correspond to the most relevant research work published during 2006-2012 (1st semester) on plant-derived compounds, plant extracts and essential oils found to elicit AChE inhibition.

show abstract

Section: Alkaloids With Ache Inhibitory Activitymentioning

confidence: 99%

Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Most of the species Amaryllidaceae (21), does not have any Amaryllidaceae alkaloids (22) and should therefore be included in the Alliaceae family. On the contrary, the isolation of the Amaryllidaceae alkaloid crinamine from the wild yam Dioscorea dregeana (Dioscoreaceae) has also proven that Amaryllidaceae alkaloids may well be encountered in other plant families (29). The classical example is the reported presence of the mesembrane (Sceletium) alkaloids, generally found in the Aizoaceae family (23,24), in a few species of Amaryllidaceae such as Hymenocallis arenicola, Crinum oliganthum, N. pallidulus, and N. triandrus (25)(26)(27).…”

Section: A Geographical Distribution and Taxonomical Aspectsmentioning

confidence: 99%

Chapter 3 Chemical and Biological Aspects of Narcissus Alkaloids

Bastida

Lavilla

Viladomat

2006

The Alkaloids: Chemistry and Biology

182

273

View full text Add to dashboard Cite

“…According to experiments carried out by Lopes [21], the extracts in hexane, dichloromethane (DCM), ethyl acetate (AcOEt), and n-butanol (n-But) from the leaves of D. piperifolia, when subjected to several tests using the agar diffusion, to evaluate the ability to inhibit the growth of pathogenic microorganisms, showed positive results, inhibiting the growth of Escherichia coli and Cryptococcus neoformans [22][23][24][25][26][27][28][29][30][31][32]. The results also showed that the relationship between the microbicide/micro biostatic effect of the extracts showed effects, except for E. coli butanol extract and methicillin-resistant Staphylococcus aureus (MRSA) in the extractions with DCM and AcOEt of the tubers [33][34][35][36][37][38][39][40] (Table 1).…”

Section: Potentialities Of the Dioscorea Genusmentioning

confidence: 99%

Dioscorea genus: A Possible Ally in the Sectors of Agriculture, Food Security and as a Source of Inputs for the Pharmaceutical Industry

Rabelo

Torres²

2021

MCDA

View full text Add to dashboard Cite

Relevance: According to the State of World Food and Nutrition Security, more than 820 million people remain hungry and 2 million are moderately or severely food insecure. The search for new raw materials rich in nutrients and present in Brazilian biodiversity is a new challenge, considering that in the current menu, only 30 species are food sources for 95% of the world's population. It is expected that new advances in research and new cultivation technologies favor the agriculture of new species with potential use as food and input for the pharmaceutical industry. In this context, we consider that the Dioscorea genus with more than 150 native species, and with some species cultivated and used in food, can be better explored as new matrices rich in nutrients for consumption and as an input for the pharmaceutical industry. The cultivation of Dioscorea species, today is developed with outdated technologies and practiced by small farmers and consequently difficult to maintain production and a delicate harvest requiring new research and technologies to increase productivity and in post-harvest operations.Objective: this review aims to provide data on native species of Dioscorea, as a possible ally in the search for efficiency in the agricultural sector, food safety and source of inputs for the pharmaceutical industry.Methodology: it was based on data from scientific publications (2000 and 2020) collected in scientific databases using the keywords: Dioscoreaceae, Dioscorea; "igname"; "yam" and "cará".Result: Dioscorea species native to Brazil have chemical diversity, richness of nutrients and other metabolites, justifying their potential use in food and input for the pharmaceutical industry and other possible applications, as we have shown. Conclusion:New research approaches and new technologies applied to the study of native species in Brazil can generate knowledge in fighting hunger and in the search for target molecules that can be commercially exploited, promoting innovation in all sectors and environmental preservation as well as sustainable use.

show abstract

The isolation of the Amaryllidaceae alkaloid crinamine from Dioscorea dregeana (Dioscoreaceae)

Cited by 16 publications

References 4 publications

Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy

Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy

Chapter 3 Chemical and Biological Aspects of Narcissus Alkaloids

Dioscorea genus: A Possible Ally in the Sectors of Agriculture, Food Security and as a Source of Inputs for the Pharmaceutical Industry

Contact Info

Product

Resources

About