The Isolation, Structure Elucidation, and Bio- and Total Synthesis of Bis-bibenzyls, from Liverworts and Their Biological Activity

Asakawa, Yoshinori

doi:10.1177/1934578x1701200845

Cited by 8 publications

(19 citation statements)

References 71 publications

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“…Secondary metabolites produced by liverworts show interesting biological activities, such as cytotoxic, antibacterial, antifungal, antiviral, and antioxidant [7,8]. They also possess muscle relaxing, tubulin inhibitory, nitric oxide production inhibitory, and calcium inhibitory activities [9]. Pellia endiviifolia (Dicks.)…”

Section: Introductionmentioning

confidence: 99%

Bis-Bibenzyls from the Liverwort Pellia endiviifolia and Their Biological Activity

Ivković

Novaković

Veljić

et al. 2021

Plants

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Based on previous investigations where bis-bibenzyls isolated from liverworts showed various biological activities (cytotoxic, antimicrobial, and antiviral), we investigated their cytotoxic activity in several human cancer cell lines. From the methylene-chloride/methanol extract of the liverwort Pellia endiviifolia, three bis-bibenzyls of the perrottetin type were isolated, namely perrottetin E, 10′-hydroxyperrottetin E, and 10,10′-dihydroxyperrottetin E. The last two were found for the first time in this species. Their structures were resolved using 1D and 2D NMR, as well as by comparison with data in the literature. Cytotoxic activity of the isolated compounds was tested on three human leukemia cell lines, HL-60 (acute promyelocytic leukemia cells), U-937 (acute monocytic leukemia cells), and K-562 (human chronic myelogenous leukemia cells), as well as on human embryonal teratocarcinoma cell line (NT2/D1) and human glioblastoma cell lines A-172 and U-251, and compared to the previously isolated bis-bibenzyls (perrottetins) of similar structure. The isolated compounds exhibited modest activity against leukemia cells and significant activity against NT2/D1 and A-172. Overall, the most active cytotoxic compounds in this investigation were perrottetin E (1), isolated in this work from Pellia endiviifolia, and perrottetin F phenanthrene derivative (7), previously isolated from Lunularia cruciata and added for a comparison of their cytotoxic activity.

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Section: Introductionmentioning

confidence: 99%

Bis-Bibenzyls from the Liverwort Pellia endiviifolia and Their Biological Activity

Ivković

Novaković

Veljić

et al. 2021

Plants

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“…Aytoniaceae, is used ethnomedicinally to stop bleeding, treat wounds and bruises in China (Asakawa, 1998;Abay, 2011). The ethanol extract contains as the main biologically active substances terpenic and bisbibenzyl phenolic compounds (riccardin C, marchantin C, M, N, O, marchantiaquinone) with antimicrobial, anticancer, antifungal, antiviral, cytotoxic, antioxidant, antiinflammatory, analgesic effects, myorelaxant antiobesity and wound healing activities (Tosun et al, 2016;Asakawa, 2017).…”

Section: Marchantiophyta (Liverworts)mentioning

confidence: 99%

Liverworts and Mosses from Romania with Medicinal Potential

Costică,

Stratu,

Costică

2023

Acta Biologica Marisiensis

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Liverworts and mosses are terrestrial plants that contain biologically active substances that give them important medicinal qualities. After reviewing the available literature on the pharmacological activity of the most used liverworts and mosses, we present 34 species found in Romania, used for the treatment of common diseases in folk medicine around the world. Their uses in traditional medicine are sometimes confirmed by pharmacological research, especially external ones (as antimicrobial or cytotoxic remedies). The species of liverworts and mosses are mentioned with their distribution in Romanian flora and the habitats where they live.

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“…Having identified the species mentioned in the original texts, their historical medicinal applications were interpreted and cross-checked with ethnopharmacological monographs (especially [ 5 ] and [ 28 ]), as well as the most recent data on their chemical components and pharmacology by [ 28 , 29 , 30 , 31 , 32 ].…”

Section: Aim Of the Workmentioning

confidence: 99%

Four Centuries of Medicinal Mosses and Liverworts in European Ethnopharmacy and Scientific Pharmacy: A Review

Drobnik

Stebel

2021

Plants

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(1) Medicinal use of bryophytes dates to ancient times, but it has always been marginal due to their small size, difficult identification, lack of conspicuous organs which would attract attention (flowers, fruits) and insipid taste of the herb. The earliest testimonies of their medical use come from the 1500s. The interest in medicinal bryophytes diminished considerably in the 1880s, except for Sphagnum spp., which became a source of dressing material. The second half of the 20th century saw the revival of the study of bryophyte chemistry. (2) Historical printed sources from 1616 to 1889 were queried. Bryophyte species found were taxonomically identified and presented against the background of their confirmed properties and ecology. The study was supplemented with historical vs. modern ethnomedicinal data. (3) In 26 publications, 28 species were identified. Modern usage was known for 10 of them. Medicinal properties of 16 species were confirmed. (4) Species of wide geographical distribution range were (or are still being) used in local folk medicines. Historical ethnobiological and ethnopharmaceutical uses of them are sometimes convergent with their confirmed properties, mostly external (as antimicrobial or cytotoxic remedies).

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The Isolation, Structure Elucidation, and Bio- and Total Synthesis of Bis-bibenzyls, from Liverworts and Their Biological Activity

Cited by 8 publications

References 71 publications

Bis-Bibenzyls from the Liverwort Pellia endiviifolia and Their Biological Activity

Bis-Bibenzyls from the Liverwort Pellia endiviifolia and Their Biological Activity

Liverworts and Mosses from Romania with Medicinal Potential

Four Centuries of Medicinal Mosses and Liverworts in European Ethnopharmacy and Scientific Pharmacy: A Review

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