The ?isolation syndrome? in mice

Valzelli, L.

doi:10.1007/bf00421275

Cited by 401 publications

(139 citation statements)

References 55 publications

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“…Isolation rearing alters neural dopamine, serotonin, and opiate systems, and changes in the synthesis, storage, or release of these transmitters or in the sensitivity of their receptors will influence social behavior (Brain & Benton, 1979;Oehler, Jähkel, & Schmidt, 1987; O'Shea, Saari, Pappas, Ings, & Stange, 1983;Schenk, Britt, Atalay, & Charleson, 1982;Valzelli, 1973). Likewise, altered neuroendocrine development in isolated animals, particularly in the hypothalamic-pituitary-adrenal and the hypothalamicpituitary-gonadal systems, may also underlie the observed deficiencies in social behavior (Brain & Benton, 1979;Hatch, Balazs, Wiberg, & Grice, 1963).…”

Section: Discussionmentioning

confidence: 99%

Effects of rearing condition, gender, and sexual experience on odor preferences and urine marking in Long-Evans rats

Brown

1991

Animal Learning & Behavior

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Two experiments investigated the effects of isolation rearing on olfactory communication in rats. In Experiment 1, there were significant rearing and gender effects on the time spent investigating conspecific odors, the preferences for these odors, and the amount of urine marking over these odors by sexually naive male and female rats. Experiment 2 found significant effects of rearing condition and sexual experience on the responses of male rats to conspecific odors. In general, isolation rearing increased the time spent investigating conspecific odors, but reduced the amount ofurine marking over these odors and altered the odor preference scales. These results suggest that the responses of both male and female rats to the odors of conspecifics are modified by rearing experience. The importance of learning conspecific odor signals for the development of normal social behavior is discussed.

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Section: Discussionmentioning

confidence: 99%

Effects of rearing condition, gender, and sexual experience on odor preferences and urine marking in Long-Evans rats

Brown

1991

Animal Learning & Behavior

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“…Dominants did not show any change in their relative preference for either chamber, whether paired with home cage or clean bedding, suggesting that bedding cues have little or no salience for dominant mice. As single-housing is suggested to stimulate dominance in male mice (36,40,63), this may be the reason that isolated mice, like dominants, failed to show a CPP.…”

Section: The Role Of Odour Cuesmentioning

confidence: 99%

“…Moreover, in the case of mice, there is good evidence that single housing of mice can result in behavioural and physiological abnormalities (22,36,37,63).…”

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confidence: 99%

There's no place like home: Cage odours and place preference in subordinate CD-1 male mice

Fitchett

Barnard

Cassaday

2006

Physiology & Behavior

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Prior studies using mice have shown that scent marks are an important source of information and can cause behavioural changes in other individuals. Studies have also shown that scent marks in the environment can affect the outcome of social interactions between mice. We used conditioned place preference tests to investigate whether CD-1 male mice (Mus musculus) are reinforced by olfactory cues from the home cage. Soiled bedding from the home cage was presented in the initially less preferred chamber of the apparatus to determine whether this association would reduce the unconditioned preference for one chamber over the other. We tested the effects of social rank and housing condition by comparing the performance of dyads that were polarised into dominant and subordinate relationships, both when paired and when separated, with mice that were isolated throughout. The development of conditioned place preference (CPP) supported by home cage odours was influenced by social rank but not by housing condition. Only subordinate mice showed CPP to home cage odours, and this effect was seen irrespective of whether they were housed with a dominant cage mate or alone. Neither dominant (paired or separated) nor isolated mice showed any change in their preference for the chamber associated with home cage odours. This suggests that the smell of home is a more powerful reinforcer for subordinate mice in that it can produce contextual conditioning to the environment in which it is experienced. Physiology & Behavior, 87,[955][956][957][958][959][960][961][962] Laboratory rodents spend a large amount of time in their home cage environment.How do they like it? It is known that the home cage can act as an effective reinforcer for mice tested in a radial maze procedure (45). However, very few studies have investigated how mice rate the home cage environment relative to alternatives, but see (59,60).An important aspect of the home environment is whether the animal is housed singly or in a group. In their natural state, house mice (Mus domesticus) typically live in social groups (24,25,26,38,48). As would be expected, what evidence there is suggests that group housing promotes welfare in laboratories (20,61,64,65).

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“…According to a group of Canadian investigators (Ba1~sz et Hatch et al, 1963), isolated rats of the Wistar strain became so aggress i ve that they cou1 d not be handl ed \IIi th bare hands and they developed caudal dermatitis. A current review of the isolation syndrome wi1) be found in Greenough (1975), and a comprehensive review of this syndrome with particular reference to mice has been prepared by Valzelli (1973).…”

Section: Can Stress Account For the Ec-ic Effects?mentioning

confidence: 99%