Abstract. We study the isomorphism problem for the multiplier algebras of irreducible complete Pick kernels. These are precisely the restrictions M V of the multiplier algebra M of Drury-Arveson space to a holomorphic subvariety V of the unit ball B d .We find that M V is completely isometrically isomorphic to M W if and only if W is the image of V under a biholomorphic automorphism of the ball. In this case, the isomorphism is unitarily implemented. This is then strengthend to show that, when d < ∞, every isometric isomorphism is completely isometric.The problem of characterizing when two such algebras are (algebraically) isomorphic is also studied. When V and W are each a finite union of irreducible varieties and a discrete variety in B d with d < ∞, then an isomorphism between M V and M W determines a biholomorphism (with multiplier coordinates) between the varieties; and the isomorphism is composition with this function. These maps are automatically weak- * continuous.We present a number of examples showing that the converse fails in several ways. We discuss several special cases in which the converse does hold-particularly, smooth curves and Blaschke sequences.We also discuss the norm closed algebras associated to a variety, and point out some of the differences.