2009
DOI: 10.1074/jbc.m806113200
|View full text |Cite
|
Sign up to set email alerts
|

The Isopeptidase Inhibitor G5 Triggers a Caspase-independent Necrotic Death in Cells Resistant to Apoptosis

Abstract: Inhibitors of the ubiquitin-proteasome system (UPSIs) promote apoptosis of cancer cells and show encouraging anti-tumor activities in vivo. In this study, we evaluated the death activities of two different UPSIs: bortezomib and the isopeptidase inhibitor G5. To unveil whether these compounds elicit different types of death, we compared their effect both on apoptosis-proficient wild type mouse embryo fibroblasts and on cells defective for apoptosis (double-deficient Bax/Bak mouse embryo fibroblasts) (double kno… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

2
50
0

Year Published

2009
2009
2022
2022

Publication Types

Select...
5
1

Relationship

1
5

Authors

Journals

citations
Cited by 31 publications
(52 citation statements)
references
References 55 publications
2
50
0
Order By: Relevance
“…Autophagy was an early response to both UPSIs and was detectable also in wild-type cells. 4 Broad and commonly used inhibitors of the autophagic process did not influence death induced by G5 in DKO cells, thus excluding the possibility that the observed death is mediated by autophagy. It is plausible that, thanks to the autophagic machinery, cells could compensate for the block of protein turnover induced by the UPSIs.…”
Section: Ups Inhibitors and Autophagymentioning
confidence: 84%
See 4 more Smart Citations
“…Autophagy was an early response to both UPSIs and was detectable also in wild-type cells. 4 Broad and commonly used inhibitors of the autophagic process did not influence death induced by G5 in DKO cells, thus excluding the possibility that the observed death is mediated by autophagy. It is plausible that, thanks to the autophagic machinery, cells could compensate for the block of protein turnover induced by the UPSIs.…”
Section: Ups Inhibitors and Autophagymentioning
confidence: 84%
“…By contrast, strengthening the adhesion to the extracellular matrix restrains G5-induced necrosis, thus further confirming a major role for the cytoskeletal changes. 4 All these features indicate that G5 activates a rather peculiar form of necrosis. We are in an initial age in the necrosis field; nevertheless examples of necrotic death involving microfilament changes are emerging.…”
Section: Ups Inhibitors and Necrosismentioning
confidence: 99%
See 3 more Smart Citations