The Isopropyl Gallate Counteracts Cyclophosphamide-Induced Hemorrhagic Cystitis in Mice

Oliveira, Lucas Solyano de Almeida de Almeida; Bandeira, Sara de Moura de Moura Raquel; Gonçalves, Rodrigo Lopes Gomes; Neto, Benedito Pereira de Sousa Pereira de Sousa; Rezende, Diana de Carvalho de Carvalho; Reis-Filho, Antonio dos dos Carlos; Sousa, Ian Jhemes Oliveira; Pinheiro-Neto, Flaviano Ribeiro; Timah, Boris; Trindade, Gabriela do Nascimento Caldas; Nascimento, Lázaro do do Gomes; Sousa, Damião Pergentino de; Almeida, Fernanda Campos Sousa de; Lucarini, Massimo; Durazzo, Alessandra; Arcanjo, Daniel Dias Rufino; Oliveira, Francisco de Assis

doi:10.3390/biology11050728

Cited by 6 publications

(5 citation statements)

References 51 publications

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“…The preventive role of Mesna against HC is not restricted to its antioxidant effect but extends to antiinflammatory and anti-apoptotic effects63. Our results of the M group when compared to the CP group revealed a significant decrease in TNF-α level which agree with Almeida de Oliveira et al, (2022) 64 . Also, the M group when compared to the CP group revealed a significant decrease in caspase expression percentage which agrees with Elrashidy and Hasan, (2021) 8 .…”

Section: Discussionsupporting

confidence: 92%

Potential Protective Effects of Mesna and Vitamin D Separately or Concomitantly on Cyclophosphamide Induced Hemorrhagic Cystitis in Rats

elkady,

Mahmoud,

Abou El-Seoud

et al. 2023

Bulletin of Pharmaceutical Sciences Assiut University

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Background: Hemorrhagic cystitis (HC) is the most common adverse effect of cyclophosphamide (CP). We assessed the protective role ofMesna and vitamin D against CP induced HC. Methods: This experiment was performed on 64 rats; CON group (control), CP group (sham cyclophosphamide), M group (Mesna), CL group (low dose calcitriol), CH group (high dose calcitriol), VD group (cholecalciferol), CM group (calcitriol & Mesna), and VDM group (cholecalciferol & Mesna). Results: Mesna and vitamin D revealed a significant decrease in visceral pain score, bladder index, malondialdehyde (MDA) and tumor necrosis factor alpha (TNF-α) levels, caspase expression, and a significant increase in total antioxidant capacity (TAC) versus the CP group. Also, the VD, CH, CM & VDM groups revealed a significant decrease in TNF-α level and caspase, microtubule-associated protein light chain 3-II (LC3-II), and sequestosome-1 (SQSTM1/p62) expression versus the M group. The CH group showed a significant increase in serum calcium versus other groups. Conclusion: Vitamin D increased the uroprotective effect of Mesna, which is attributed to its ability to restore autophagy flux.

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Section: Discussionsupporting

confidence: 92%

Potential Protective Effects of Mesna and Vitamin D Separately or Concomitantly on Cyclophosphamide Induced Hemorrhagic Cystitis in Rats

elkady,

Mahmoud,

Abou El-Seoud

et al. 2023

Bulletin of Pharmaceutical Sciences Assiut University

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“…Acrolein has the ability to induce the breakdown of the intraluminal membrane, facilitating its penetration of the underlying epithelium along with initiating an inflammatory process, causing edema, neutrophil infiltration, hemorrhage and devastating tissue damage 54 , 55 .…”

Section: Discussionmentioning

confidence: 99%

Protective effects of hesperidin in cyclophosphamide-induced parotid toxicity in rats

Mostafa

Ibrahim

Borai

2023

Sci Rep

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Cyclophosphamide (CYP) is an alkylating agent that is used on a wide range as a treatment of malignancies and autoimmune diseases. Previous studies have shown the promising role of hesperidin (HSP) as an antioxidant agent against various models of toxic agents. The protective effect of the HSP against CYP-induced parotid damage was evaluated in this study. Forty rats (180–200 g) were divided into four equal groups: Group I (received normal saline), Group II (HSP-treated at a dose of 100 mg/kg/day for 7 consecutive days), Group III (CYP-treated at a dose of 200 mg/kg single intraperitoneal injection on the 7th day of the experiment), Group IV (CYP + HSP); HSP-treated at a dose of 100 mg/kg/day for 7 consecutive days and CYP (200 mg/kg) single intraperitoneal injection on the 7th day of the experiment. Afterwards, the oxidative stress and inflammatory markers, the histopathological and immunohistochemical alterations of the parotid tissues in the studied groups were evaluated. CYP intoxication induced a significant parotid tissue injury represented by the elevation in the values of malondialdehyde (MDA), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) and decrease in the catalase activity and glutathione peroxidase (GPx). Histologically, extensive histopathological alterations e.g., widely spaced serous acini with irregular shapes and congested blood vessels as well as downregulated ki-67 and alpha-smooth muscle actin (α-SMA) immunoexpression were induced by CYP. HSP administration markedly improved the biochemical and the histopathological studies. We can conclude that HSP elicited protective effects against the CYP-induced parotid toxicity.

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“…The adverse effects include: i) Hemorrhagic cystitis, hemorrhagic cystitis caused by drugs is considered to be the cause of hematuria, dysuria, and frequency, and includes a variety of antineoplastic agents (cyclophosphamide), antibiotics (penicillin), and others (nonsteroidal anti‐inflammatory drugs, etc.) [ 68 ] ii) Uroschesis, urination is a complicated physiological process. In the beginning of urination, the nerve impulse to the α adrenal receptor at the neck of the bladder is weak, while the parasympathetic nerve, which maintains the tension of the detrusor muscle, will be excited, so that the urine can be discharged completely.…”

Section: Luts Overviewmentioning

confidence: 99%

Advanced Sensoring Technologies for Evaluation and Management of Lower Urinary Tract Symptoms

Gong

Ding

Jiao

et al. 2023

Advanced Sensor Research

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Nowadays, urination dysfunction caused by lower urinary tract symptoms (LUTS) has been a nonnegligible issue owing to its influences on patients’ physical and mental health, and in particular, the detection of the urination process and analysis of the urine samples of the patients have been the priority for diagnosis and treatment of LUTS. In this article, the existing perception of LUTS, such as the etiologies of LUTS and current approaches for LUTS evaluation in the clinic, is systematically summarized. Furthermore, several novels lower urinary tract (LUT) status‐sensing systems used for monitoring physiological indexes, including intravesical pressure, urine flow rate, residue urine volume, bladder volume, and biomarkers in urine, are introduced. It is believed that this presentation will make a contribution to deepening the comprehension of LUTS and promote the development of rapid, accurate, and convenient LUT testing techniques.

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The Isopropyl Gallate Counteracts Cyclophosphamide-Induced Hemorrhagic Cystitis in Mice

Cited by 6 publications

References 51 publications

Potential Protective Effects of Mesna and Vitamin D Separately or Concomitantly on Cyclophosphamide Induced Hemorrhagic Cystitis in Rats

Potential Protective Effects of Mesna and Vitamin D Separately or Concomitantly on Cyclophosphamide Induced Hemorrhagic Cystitis in Rats

Protective effects of hesperidin in cyclophosphamide-induced parotid toxicity in rats

Advanced Sensoring Technologies for Evaluation and Management of Lower Urinary Tract Symptoms

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