The Isoxazolyl Penicillins: Oxacillin, Cloxacillin, and Dicloxacillin

Na2S2O3 Catalyzed Three‐Component Synthesis and Anti‐Bacterial Activity of 3‐Methyl‐4‐(hetero)arylmethylene isoxazole‐5(4H)‐ones

“…Infrared (IR) spectra were recorded on a Japanese Shimadzu IRAffinity-1s instrument in the range between 500 and 3500 cm À 1 , KBr pellet was used as a control. 1 H and 13 C NMR spectra were recorded by using a Germany Bruker 400 NMR spectrometer in DMSO-d 6 or CDCl 3 with tetramethyl silane (TMS) acting as an internal standard.…”

“…Isoxazole and its derivatives are an important class of nitrogen–containing heterocyclic compounds with excellent biological and pharmaceutical activities, which have good performance in the fields of antibacterial, anti–inflammatory, anti–virus, anti–tumor and anti–diabetes [5–12] . Many drugs containing isoxazole structure have been used in clinic, such as oxacillin, cloxacillin and dichloropenicillin, which are all effective penicillin antibiotics and can be used for bacterial infection [13] . Especially, recent studies have found that substituted isoxazolone has good resistance to some bacteria like Gram negative bacteria, Gram positive bacteria and mycobacterium tuberculosis [14,15] .…”

“…[5][6][7][8][9][10][11][12] Many drugs containing isoxazole structure have been used in clinic, such as oxacillin, cloxacillin and dichloropenicillin, which are all effective penicillin antibiotics and can be used for bacterial infection. [13] Especially, recent studies have found that substituted isoxazolone has good resistance to some bacteria like Gram negative bacteria, Gram positive bacteria and mycobacterium tuberculosis. [14,15] Thus, the synthesis of isoxazolone derivatives is of great importance.…”

Cephalotin Versus Dicloxacillin for the Treatment of Methicillin-Susceptible Staphylococcus aureus Bacteraemia: A Retrospective Cohort Study

“…Dicloxacillin and nafcillin have similar pharmacokinetic properties, but nafcillin can only be used intravenously while dicloxacillin is well absorbed after oral and intramuscular administration [7][8][9][10]. Cefazolin has some advantages over cephalotin after intravenous administration.…”

Ni‐Ferrite an efficient catalyst for synthesis of 3‐aryl substituted isoxazole‐5‐carboxylic acids via one‐pot multicomponent reaction

“…Isoxazole and its derivatives are found in various natural products, physiologically active compounds, and functional materials [3]. Further, isoxazole core possesses a wide spectrum of biological targets and properties, such as anti‐inflammatory [10], antibiotic [11], antirheumatic [12], antidepressant [13], anticancer [14], and antifungal [15]. Due to their range of biological properties and structural flexibility, the synthesis of isoxazole derivatives offers attractive options and possibilities for medicinal chemistry [16–18].…”