2020
DOI: 10.3390/antibiotics9050269
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The Israeli Phage Bank (IPB)

Abstract: A key element in phage therapy is the establishment of large phage collections, termed herein “banks”, where many well-characterized phages, ready to be used in the clinic, are stored. These phage banks serve for both research and clinical purposes. Phage banks are also a key element in clinical phage microbiology, the prior treatment matching of phages and antibiotics to specific bacterial targets. A worldwide network of phage banks can promote a phage-based solution for any isolated bacteria. Herein, we desc… Show more

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Cited by 43 publications
(39 citation statements)
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“…A key precondition in phage application is an eligible phage library (phage bank) with broad-spectrum, poly antimicrobial properties, where many well-characterized phages are constantly collected and arranged according to the host species. Although an increasing number of phage libraries has been established recently, the overall scale is small and the information in most of the existing phage collections is incomplete ( Table 1 ) ( Yerushalmy et al, 2020 ). This strongly limits wide access to phage therapy since not all patients can afford the time-consuming process of mailing pathogenic bacteria from a healthcare facility to a phage repository, followed by screening lytic phages and mailing therapeutic phages back; neither can they afford time for de novo phage screening from nature.…”
Section: Establishing a Phage Library With Broad-spectrum And Poly Anmentioning
confidence: 99%
See 1 more Smart Citation
“…A key precondition in phage application is an eligible phage library (phage bank) with broad-spectrum, poly antimicrobial properties, where many well-characterized phages are constantly collected and arranged according to the host species. Although an increasing number of phage libraries has been established recently, the overall scale is small and the information in most of the existing phage collections is incomplete ( Table 1 ) ( Yerushalmy et al, 2020 ). This strongly limits wide access to phage therapy since not all patients can afford the time-consuming process of mailing pathogenic bacteria from a healthcare facility to a phage repository, followed by screening lytic phages and mailing therapeutic phages back; neither can they afford time for de novo phage screening from nature.…”
Section: Establishing a Phage Library With Broad-spectrum And Poly Anmentioning
confidence: 99%
“…Criteria of eligible phage candidates have been extensively discussed and, although estimates of index values vary among groups, there’s a general consensus that the key features that must be characterized include: host species, complete genome sequence (to exclude or to allow modification of phages with known integration/toxic/resistance genes), host range testing, and high lytic activity ( Gill and Hyman, 2010 ; Letarov and Kulikov, 2018 ; Merabishvili et al, 2018 ). Some other factors such as high yield, identified receptor, morphology, anti-biofilm activity, low resistance induction, stability during storage, and pre-clinical evaluation (e.g., safety, efficacy, pharmacodynamics and pharmacokinetics, human immune responses) are generally considered to be important during optimization of phages for therapeutics ( Malik et al, 2017 ; D´abrowska and Abedon, 2019 ; Hesse and Adhya, 2019 ; Kortright et al, 2019 ; Yerushalmy et al, 2020 ).…”
Section: Establishing a Phage Library With Broad-spectrum And Poly Anmentioning
confidence: 99%
“…Personalized phage therapy, which consists of matching a phage to a bacterial isolate, requires a collection of phages usually referred to as phage bank. As pointed out by Yerushalmy et al [ 24 ], a phage bank should contain well-characterized phages that are ready to be used in clinical trials against as many strains of bacteria as possible. A well-known source of phages for researchers is ATCC.…”
Section: Phage Therapy As Precision Medicinementioning
confidence: 99%
“…It has been observed that majority of research groups are interested in bacteriophages against ESKAPE pathogens and enterobacteriaceae, owing to their higher disease prevalence, involved economic burden and severe consequences. Accordingly, out of very few phage banks established till date, most have collection of lytic bacteriophages against these pathogens 17 . Research groups involved in isolation of bacteriophages against deadly pathogens have been working with Mycobacterium sp., Brucella sp., Burkholderia sp., Bacillus sp., Clostridium sp., Propionibacterium sp., Streptococcus sp., Yersinia sp., Mannheimia sp., etc.…”
Section: Bacteriophage Bankmentioning
confidence: 99%