The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology

Harding, Simon D; Faccenda, Elena; Southan, Christopher; Pawson, Adam J.; Maffia, Pasquale; Alexander, Stephen P.H.; Davenport, Anthony P.; Fabbro, Doriano; Levi‐Schaffer, Francesca; Spedding, Michael; Davies, Jamie A.

doi:10.1111/imm.13175

Cited by 7 publications

(4 citation statements)

References 62 publications

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“…Detailed help and tutorials are provided on our website and we have previously written a protocol paper about accessing data in GtoPdb ( 15 ), and for the IUPHAR Guide to Immunopharmacology, we have described a use-case on how the resource can support research in vascular inflammation ( 9 ).…”

Section: Guide To Pharmacology Updatesmentioning

confidence: 99%

The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials

Harding

Armstrong

Faccenda

et al. 2021

Nucleic Acids Research

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140

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The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; www.guidetopharmacology.org) is an open-access, expert-curated database of molecular interactions between ligands and their targets. We describe expansion in content over nine database releases made during the last two years, which has focussed on three main areas of infection. The COVID-19 pandemic continues to have a major impact on health worldwide. GtoPdb has sought to support the wider research community to understand the pharmacology of emerging drug targets for SARS-CoV-2 as well as potential targets in the host to block viral entry and reduce the adverse effects of infection in patients with COVID-19. We describe how the database rapidly evolved to include a new family of Coronavirus proteins. Malaria remains a global threat to half the population of the world. Our database content continues to be enhanced through our collaboration with Medicines for Malaria Venture (MMV) on the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY (www.guidetomalariapharmacology.org). Antibiotic resistance is also a growing threat to global health. In response, we have extended our coverage of antibacterials in partnership with AntibioticDB.

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Section: Guide To Pharmacology Updatesmentioning

confidence: 99%

The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials

Harding

Armstrong

Faccenda

et al. 2021

Nucleic Acids Research

Self Cite

140

110

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“…In this issue of Immunology, we highlight and discuss one of the latest of those database resources, the Guide to Immunopharmacology (GtoImmuPdb; www.guidetoim munopharmacology.org). 1 The guide has been created, developed and maintained by the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS), in collaboration with the International Union of Immunological Societies (IUIS). The database was initially established with the support of the Wellcome Trust.…”

Section: Discussionmentioning

confidence: 99%

Guide to Immunopharmacology: a database to boost immunology education, research and therapy

Milling

Spedding²,

Maffia

2020

Immunology

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Summary In the era of big data, the establishment of a free database, containing all the immune drug targets and associated cell types, is of great value. To this aim, the Guide to Immunopharmacology has been created in a joint effort between the International Union of Basic and Clinical Pharmacology (IUPHAR) and the International Union of Immunological Societies (IUIS). Here we highlight the structure and content of the database, which includes up‐to‐date quantitative information on the fundamental science underlying each immune target. A set of practical examples and tools for data mining are summarized to support immune research into drug discovery and therapeutics.

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“…Key protein targets and ligands in this article are hyperlinked to corresponding entries in https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10906, the common portal for data from the IUPHAR/BPS Guide to PHARMACOLOGY 11 …”

Section: Methodsmentioning

confidence: 99%

A case series of confusional states and other neurotoxic effects caused by ertapenem

Danés

Pérez

Pigrau

et al. 2020

Brit J Clinical Pharma

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Ten cases of ertapenem neurotoxicity, mainly confusional states, are described, some of them with fatal outcomes. The majority of patients (90%) had a creatinine clearance (CrCl) < 50 mL/min/1.73m 2 at some point during treatment and hypoalbuminaemia was always present when ertapenem treatment was started. The pharmacokinetic and pharmacodynamic properties of this carbapenem could favour a different profile, and approved doses can be excessive in some patients with moderate renal failure (CrCl 31-59 mL/min/1.73 m 2). It may be necessary to re-evaluate renal function during treatment and adjust doses or reconsider the adequacy of treatment based on clinical judgement, especially if relevant changes in the CrCl occur (i.e. a reduction to ≤30 mL/min/1.73 m 2) or unexplained behavioural disorders are detected. The onset of the symptoms of ertapenem neurotoxicity can be insidious and go unnoticed, and so a knowledge and early suspicion of confusional states are important to improve the patient prognosis.

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The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology

Cited by 7 publications

References 62 publications

The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials

The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials

Guide to Immunopharmacology: a database to boost immunology education, research and therapy

A case series of confusional states and other neurotoxic effects caused by ertapenem

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