The J‐shaped relationship between body mass index and mortality in patients with COVID‐19: A dose‐response meta‐analysis

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has caused a considerable number of deaths. Identifying individuals at higher risk of

Association of obesity with postacute sequelae of COVID‐19

“…Collectively, the findings of this study suggest that patients with obesity are at a greater risk of developing PASC. This observation can be explained by all underlying mechanisms that deteriorate clinical outcomes during the acute phase of COVID‐19 in patients with obesity, including obesity‐related hyperinflammation, immune dysfunction and co‐morbidities 5‐11 …”

“…This observation can be explained by all underlying mechanisms that deteriorate clinical outcomes during the acute phase of COVID-19 in patients with obesity, including obesity-related hyperinflammation, immune dysfunction and co-morbidities. [5][6][7][8][9][10][11] Reports are emerging in the literature on different aspects of PASC, including its epidemiology, risk factors, pathophysiology, clinical pictures and consequences. [1][2][3][4] Four months after hospitalization, in an uncontrolled cohort study of 478 survivors of COVID-19, at least one new-onset symptom was reported by telephone interview in 51%, including fatigue (31%), cognitive symptoms (21%) and dyspnoea (16%).…”

“…Obesity is a major risk factor for development of severe COVID‐19 infection and mortality. Obesity, as a pro‐inflammatory and pro‐thrombotic disease, can impair the immune system, and is associated with cardiovascular, pulmonary and metabolic disorders that can worsen the outcomes of COVID‐19 infection during the acute phase 5‐11 . However, it is not known whether patients with obesity are at a greater risk of developing PASC.…”

COVID-19 infection and body weight: A deleterious liaison in a J-curve relationship

“…A meta-analysis of 28 studies comprising 112,682 COVID-19 patients showed that those with a high BMI had an elevated risk of mortality (pooled RR 1.33; P < 0.001), with moderate heterogeneity ( I 2 = 54.2%). 50 A positive dose-response association between BMI and mortality was found based on the linear model. However, a significant nonlinear relationship between BMI and mortality was observed.…”

Respiratory and nonrespiratory COVID-19 complications in patients with obesity: recent developments

“…Despite the large sample size, 28% of patients across the 238 included hospitals were missing height or weight information, precluding inclusion in the study. A recent study by Huang et al [ 37 ] suggests that this J-shaped relationship – which highlights an association between overweight (20–25 kg/m 2 ) and lower mortality – may be attributable to issues with reverse causation and the presence of confounders.…”