The Jarisch–Herxheimer reaction: Revisited

Belum, Geetanjali Reddy; Belum, Viswanath Reddy; Arudra, Sri Krishna Chaitanya; Reddy, B. Naresh Kumar

doi:10.1016/j.tmaid.2013.04.001

Cited by 97 publications

(98 citation statements)

References 59 publications

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“…Yang et al described a rate as high as 34.6% in HIV-infected patients ( 8 ). Th e Jarisch-Herxheimer reaction is a transient immunological phenomenon seen commonly in patients during treatment of secondary syphilis; it manifests with constitutional symptoms such as fever, chills, headache, and myalgias in addition to exacerbation of existing cutaneous lesions ( 9 ). Th e reaction usually occurs soon after the administration of an appropriate antibiotic (2-24 hours) and usually resolves without any intervention, generally within 24 hours.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Nodular-Ulcerative Form of Secondary Syphilis in Aids

Gevorgyan¹,

Owen²,

Balavenkataraman³

et al. 2017

Baylor University Medical Center Proceedings

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Section: Discussionmentioning

confidence: 99%

“…Th e reaction usually occurs soon after the administration of an appropriate antibiotic (2-24 hours) and usually resolves without any intervention, generally within 24 hours. Jarisch-Herxheimer reaction is more severe when the number of organisms is abundant ( 9 ). No specifi c tests are available to diagnose Jarisch-Herxheimer reaction.…”

Section: Discussionmentioning

confidence: 99%

A Nodular-Ulcerative Form of Secondary Syphilis in Aids

Gevorgyan¹,

Owen²,

Balavenkataraman³

et al. 2017

Baylor University Medical Center Proceedings

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“…These may be anti-oxidants, proteinase, elastase and PLA2 inhibitors, and anticytokines and perhaps even IV-IgG. Also, since microbial agents undergoing bacteriolysis release a variety of PAMPs [16][17][18][19][20], it could also be considered that the antibiotics used for septic patients should perhaps be bacteriostatic but not bactericidal, thus avoiding a JarischHerxheimer-like phenomenon [25].…”

Section: Journal Of Infectious Diseases and Therapymentioning

confidence: 99%

Is Histone a Solitary Vile Sepsis-Inducing Agent or Just "a Member of the Gang"?

Ginsburg¹,

Koren²,

Trahtemberg³

et al. 2017

J Infect Dis Ther

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In this communication we argue that it is improbable that the main cause of death in sepsis is that, upon release of extracellular traps from neutrophils adhering to endothelial cells, highly cationic toxic histones uniquely cause endothelial dysregulation, organ failure and death. Activation of neutrophils is always accompanied by a plethora of pro-inflammatory agents, which may act in synergy with histones to injure cells. Furthermore, many recent articles have shown a steep rise of circulating histones in many clinical disorders unrelated to sepsis. We argue therefore that histones do not act as unique alarmins with an outsized role, but are probably another marker of cell damage.

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“…This reaction occurs within 24 hours after the start of any recommended antimicrobial agent and it resolves without serious consequences within 24 hours, with no evidence of recurrence and any relationship with the outcome of the current treatment [11]. There is no conformity about incidence data of this phenomenon in relation to different spirochetes and to different therapeutic or prophylactic strategies of LD, however, an increase in the incidence may be expected among patients co-infected with HIV and other infectious diseases including syphilis [56].…”

Section: Jarisch-herxheimer Reactionmentioning

confidence: 99%

Therapy of Lyme Disease

Trevisan¹,

Errichetti²,

Meo³

et al. 2016

TODJ

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Borrelia burgdorferi is highly susceptible to antibiotic treatment and the majority of patients profit from this treatment. Antibiotic selection, dose and route of administration, and duration of therapy for Lyme disease depend on the patient's clinical manifestations and stage of disease, age, pregnancy status, as well as the presence of other concomitant diseases and/or allergies. Despite an appropriate antibiotic therapy, about 10-20% of patients may show persistent or recurrent symptoms ("post-treatment Lyme disease syndrome").In the present paper we will briefly discuss the post-exposure prophylaxis, before going on to talk over the current therapeutic approach regarding the management of Lyme disease according to the stage of disease/clinical manifestations. Finally, we will discuss the main treatment-related phenomenon, the Jarisch-Herxheimer reaction, and the treatment modalities for special categories of patients, namely pregnant women, subjects suffering from post-treatment Lyme disease syndrome, possible Borrelia-associated skin manifestations, coinfections and Baggio-Yoshinary syndrome.

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The Jarisch–Herxheimer reaction: Revisited

Cited by 97 publications

References 59 publications

A Nodular-Ulcerative Form of Secondary Syphilis in Aids

A Nodular-Ulcerative Form of Secondary Syphilis in Aids

Is Histone a Solitary Vile Sepsis-Inducing Agent or Just "a Member of the Gang"?

Therapy of Lyme Disease

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