The joint association of anxiety, depression and obesity with incident asthma in adults: the HUNT Study

Brumpton, Ben; Leivseth, Linda; Romundstad, Pål Richard; Langhammer, Arnulf; Chen, Yue; Camargo, Carlos A.; Mai, Xiao-Mei

doi:10.1093/ije/dyt151

Cited by 38 publications

(37 citation statements)

References 42 publications

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“…As in our trial, other studies have shown that depression is more common in women [24] and in populations with higher unemployment [25] and lower socio-economic status [26]. Anxiety is the most common comorbidity [27] and it is also correlated witho obesity [28]. …”

Section: Resultssupporting

confidence: 64%

Depressed patients treated by homeopaths: a randomised controlled trial using the “cohort multiple randomised controlled trial” (cmRCT) design

Viksveen

Relton

Nicholl

2017

Trials

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BackgroundDespite controversy regarding homeopathy, some patients consult homeopaths for depression. Evidence is required to determine whether this is an effective, acceptable and safe intervention for these patients.MethodsA pragmatic trial using the “cohort multiple randomised controlled trial” design was used to test the effectiveness of adjunctive treatment by homeopaths compared to usual care alone, over a period of 12 months in patients with self-reported depression. One third of patients were randomly selected for an offer of treatment provided by a homeopath. The primary outcome measure was the Patient Health Questionnaire (PHQ-9) at 6 months. Secondary outcomes included depression scores at 12 months; and the Generalised Anxiety Disorder (GAD-7) outcome at 6 and 12 months.ResultsThe trial over-recruited by 17% with a total of 566 patients. Forty percent took up the offer and received treatment. An intention-to-treat analysis of the offer group at 6 months reported a 1.4-point lower mean depression score than the no offer group (95% CI 0.2, 2.5, p = 0.019), with a small standardized treatment effect size (d = 0.30). Using instrumental variables analysis, a moderate treatment effect size in favour of those treated was found (d = 0.57) with a between group difference of 2.6 points (95% CI 0.5, 4.7, p = 0.018). Results were maintained at 12 months. Secondary analyses showed similar results. Similar results were found for anxiety (GAD-7). No evidence suggested any important risk involved with the intervention.ConclusionThis trial provides preliminary support for both the acceptability and the effectiveness of treatment by a homeopath for patients with self-reported depression. Our results provide support for further pragmatic research to provide more precise estimates of treatment effect.Trial registrationISRCTN registry, ISRCTN02484593. Registered on 7 January 2013.Electronic supplementary materialThe online version of this article (doi:10.1186/s13063-017-2040-2) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 64%

Depressed patients treated by homeopaths: a randomised controlled trial using the “cohort multiple randomised controlled trial” (cmRCT) design

Viksveen

Relton

Nicholl

2017

Trials

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“…Other studies have also shown that diagnosed asthma and current wheezing were associated with diagnosed depression and anxiety [31,32]. An increased risk of incident asthma at follow-up was found in adults who reported symptoms of anxiety or depression at baseline in a large prospective study on the general population of Norway [33].…”

Section: Discussionmentioning

confidence: 90%

Impact of anxiety and depression on respiratory symptoms

Leander

Lampa

Rask‐Andersen

et al. 2014

Respiratory Medicine

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Psychological factors such as anxiety and depression are prevalent in patients with asthma. The purpose of this study was to investigate the relationship between respiratory symptoms and psychological status and to estimate the importance of psychological status in comparison with other factors that are known to be associated with respiratory symptoms. This study included 2270 subjects aged 20-44 (52% female) from Sweden, Iceland, and Norway. Each participant underwent a clinical interview including questions on respiratory symptoms. Spirometry and methacholine challenge were performed. Symptoms of depression and anxiety were measured using the Hospital Anxiety and Depression Scale (HADS). Eighty-two percent of the subjects reported no anxiety or depression whatsoever, 11% reported anxiety, 2.5% depression and 4% reported both anxiety and depression. All respiratory symptoms, such as wheezing, breathlessness and nightly symptoms, were more common, at a statistically significant level, in participants who had depression and anxiety, even after adjusting for confounders (ORs 1.33-1.94). The HADS score was the most important determinant for nightly symptoms and attacks of breathlessness when at rest whereas bronchial responsiveness was the most important determinant for wheezing, and breathlessness when wheezing. The probability of respiratory symptoms related to HADS score increased with increasing HADS score for all respiratory symptoms. In conclusion, there is a strong association between respiratory symptoms and psychological status. There is therefore a need for interventional studies designed to improve depression and anxiety in patients with respiratory symptoms.

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“…Patients who are actively involved in a trusting nurse-patient relationship have been found to experience increased adherence to treatment protocols (Elder et al, 2012;Blackstock, Addison, Brennam, & Alao, 2012), increased likelihood of lifestyle and behavioral change (Jones, Carson, Bleich, & Cooper, 2012), and higher patient satisfaction with care (Shan et al, 2016;Bohnert, Zivin, Welsh, & Kilbourne, 2011), leading to improved healthcare outcomes. In addition, Brumpton et al, (2013) ascertained the therapeutic effect of a trusting nurse-patient relationship. They found that chronic stress acted as a pathologic trigger in asthma incidents among adult patients, and by controlling stress through the trusting nurse-patient relationship, asthma incidents were reduced.…”

Section: Trusting Nurse-patient Relationshipmentioning

confidence: 99%

Patient Satisfaction With Caring at a District Hospital in Malawi

Nkwinda¹,

Jacobs²,

Downing³

2018

GJHS

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PURPOSE: The purpose of this study was to investigate and understand patient satisfaction with caring at a district hospital in Malawi. MATERIALS & METHODS: The study used a mixed methods design, employing the sequential explanatory strategy. A total of 120 adult patients completed a survey questionnaire (phase one), and of these, two patients were followed up with individual interviews (phase two). RESULTS: Data were analyzed using statistical procedures, thematic analysis and an integration process of quantitative and qualitative findings. Highest patient satisfaction (90.6%; M=4.53; SD=0.879) occurred with nurses’ presence; while lowest satisfaction (37.4%; M=1.87; SD=1.710) was seen with patient teaching. Patients’ lived experiences revealed that nurses’ demonstration of presence and professional proficiency were critical to caring. UNIQUE CONTRIBUTION TO THEORY, PRACTICE AND POLICY: To enhance improved caring, there was a need for nurses to increase personal presence, promote patient involvement in decision-making, and demonstrate competent confidence.

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The joint association of anxiety, depression and obesity with incident asthma in adults: the HUNT Study

Abstract: This study suggests that having anxiety or depression symptoms contributes to the development of asthma in adults. The risk of asthma may be further increased by the interaction between anxiety or depression symptoms and obesity.

Cited by 38 publications

References 42 publications

Depressed patients treated by homeopaths: a randomised controlled trial using the “cohort multiple randomised controlled trial” (cmRCT) design

Depressed patients treated by homeopaths: a randomised controlled trial using the “cohort multiple randomised controlled trial” (cmRCT) design

Impact of anxiety and depression on respiratory symptoms

Patient Satisfaction With Caring at a District Hospital in Malawi

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