The joint effects of arsenic and risk diplotypes of insulin-like growth factor binding protein-3 in renal cell carcinoma

Huang, Chao Yuan; Huang, Ya; Pu, Yeong-Shiau; Shiue, Horng Sheng; Chen, Wei-Jen; Chen, Shih Shan; Lin, Ying‐Chin; Su, Chien Tien; Hsueh, Yu Mei

doi:10.1016/j.chemosphere.2016.03.056

Cited by 5 publications

(2 citation statements)

References 63 publications

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“…All nine case-control studies reporting on the relationship between As exposure and kidney cancer focused on incidence, and these were mostly from Taiwan (n = 7) (Table 5). Six studies [69][70][71][72][73][74] used urinary As concentrations as the metric of exposure and observed a consistent dose-response relationship between the incidence of kidney cancer and the concentration of urinary As. Similarly, Chen et al [44] found a positive relationship between the incidence of kidney cancer and an increasing arseniasis grade, reporting rates of 3.92, 4.71, 5.31 and 8.35 per 100,000 person-years for arseniasis grades 0, 1, 2 and 3, respectively.…”

Section: Case-control Studiesmentioning

confidence: 96%

“…Information about missing data and methods for handling missing data were rarely described in the included studies. Sixteen of the 34 studies did not provide any information regarding missing data [43,45,46,48,50,53,[58][59][60]62,68,[70][71][72][73][74], whereas nine excluded >10% of the data due to missingness without attempting to handle the missing data [42,44,51,55,[63][64][65]67,75]. The studies also varied in terms of measuring outcomes.…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Arsenic in Drinking Water and Urinary Tract Cancers: A Systematic Review Update

Issanov,

Adewusi,

Dummer

et al. 2023

Water

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There remains uncertainty around cancer risk at lower levels of arsenic in drinking water. This study updates evidence from our previous review on the relationship between arsenic in drinking water and urinary bladder and kidney cancers (updated search January 2013 to February 2023). Method: Thirty-four studies were retained for review; six met criteria for inclusion in meta-analysis. Risk estimates for bladder and kidney cancer incidence and mortality were analyzed separately using Bayesian multilevel linear models. Results: For bladder cancer incidence, the estimated posterior mean relative risks (RRs) were 1.25 (0.92–1.73), 2.11 (1.18–4.22) and 3.01 (1.31–8.17) at arsenic concentrations of 10, 50 and 150 μg/L, respectively, with posterior probabilities of 92%, 99% and 100%, respectively, for the RRs to be >1. The corresponding RRs for kidney cancer were 1.37 (1.07–1.77), 1.95 (1.44–2.65) and 2.47 (1.74–3.52), with posterior probabilities of 100%. For bladder cancer, the posterior mean mortality ratios were 1.36 (0.35–6.39), 2.92 (1.24–7.82) and 4.88 (2.83–9.03) with posterior probabilities of 72%, 99% and 100%, respectively. Conclusions: The findings show increased bladder and kidney cancer risks at lower levels of arsenic in drinking water. Given that many people worldwide are exposed to lower levels of arsenic in drinking water, the public health impacts are substantial.

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