The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Physical Activity and Sedentary Behavior

Barbieri, Elena; Falcieri, Elisabetta; Santi, Mauro De; Natalucci, Valentina; Vallorani, Luciana; Agostini, Deborah; Annibalini, Giosuè; Stefani, Laura; Szychlinska, Marta Anna; Musumeci, Giuseppe

doi:10.3390/jfmk3020023

Cited by 1 publication

(1 citation statement)

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“…PA as a nonpharmacological treatment to combat the collateral effects associated with BC is under considerable scientific attention [ 160 , 165 , 166 ]. To allow physicians to prescribe PA to patients before and after treatment, scientific clarity and evidence supporting the thesis that PA programs reduce the damaging effects of cancer and its treatment are needed.…”

Section: Benefits Of Exercise Pre- and Postdiagnosesmentioning

confidence: 99%

New Insights into the Role of Exercise in Inhibiting mTOR Signaling in Triple‐Negative Breast Cancer

Agostini

Natalucci

Baldelli

et al. 2018

Oxidative Medicine and Cellular Longevity

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Triple-negative breast cancer (TNBC) does not express estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 and is characterized by its aggressive nature, lack of targets for targeted therapies, and early peak of recurrence. Due to these specific characteristics, chemotherapy does not usually yield substantial improvements and new target therapies and alternative strategies are needed. The beneficial responses of TNBC survivors to regular exercise, including a reduction in the rate of tumor growth, are becoming increasingly apparent. Physiological adaptations to exercise occur in skeletal muscle but have an impact on the entire body through systemic control of energy homeostasis and metabolism, which in turn influence the TNBC tumor microenvironment. Gaining insights into the causal mechanisms of the therapeutic cancer control properties of regular exercise is important to improve the prescription and implementation of exercise and training in TNBC survivors. Here, we provide new evidence of the effects of exercise on TNBC prevention, control, and outcomes, based on the inhibition of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (PKB also known as Akt)/mammalian target of rapamycin (mTOR) (PI3K-Akt-mTOR) signaling. These findings have wide-ranging clinical implications for cancer treatment, including recurrence and case management.

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Section: Benefits Of Exercise Pre- and Postdiagnosesmentioning

confidence: 99%