The purpose of the study was to conduct a comprehensive analysis of current issues related to the protection of patientsʼ rights in healthcare systems in Europe and the United States. For this purpose, a comparative analysis of the legal acts in the United States of America and Europe ensuring patientsʼ rights was carried out, using terminological, formal legal, structural and functional methods, and problem analysis. The results obtained show that the legal provisions on patientsʼ rights in Europe and the USA include the rights to access to quality medical care, confidentiality of medical information, participation in the decision-making process regarding treatment, and the right to access medical services without discrimination on any grounds. A review of the obstacles faced by European and American patients in protecting their rights in the 21st century has shown that measures should be taken to raise standards and make healthcare more accessible to all. It is particularly important to create a more effective system of monitoring the observance of patientsʼ rights and the application of modern healthcare standards. In the future, it will be relevant to monitor the development of digital medical technologies and improve the health literacy of the population. The recommendations include the creation of patient rights training plans, professional development of healthcare professionals and ensuring more open and transparent healthcare governance, strengthening of legislative regulation, improving access to healthcare, protection of personal data, development of telemedicine, raising awareness of patientsʼ rights, reforming the insurance system, and monitoring and evaluation of the quality of healthcare. These recommendations will contribute to improving the healthcare system, ensuring the protection of patientsʼ rights and reducing inequalities in access to healthcare in the US and Europe