The Keloid Area and Severity Index (KASI): an objective tool for the evaluation of keloids

Limmer, Emily E.; Kerby, Eva; Lies, Shelby; Limmer, Byron; Limmer, Rachel; Teske, Noelle; Savory, Stephanie; Reisch, Joan; Glass, Donald A.

doi:10.1111/bjd.21705

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…It includes both an activity score and a damage score, with contribution from lesion characteristics of erythema, suppuration/crust, elevation and percent body surface area covered (Table 5). Currently, an analysis is underway to establish the inter‐rater and intrarater reliability levels to determine the validity of the proposed index 13 …”

Section: Resultsmentioning

confidence: 99%

“…Darker skin tones have more melanin in the skin, leading to darker and more pronounced scars that can affect the accuracy of assessments that rely on colour-based scales or images produced by cameras. Inter-rater reliability was moderate for activity scoring, excellent for damage scoring 13 Ease of use…”

Section: Vas With Scar Rankingmentioning

confidence: 96%

“…Currently, an analysis is underway to establish the inter-rater and intrarater reliability levels to determine the validity of the proposed index. 13 Detroit Keloid Scale (DKS)…”

Section: Shear Wave Elastography (Swe)mentioning

confidence: 99%

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Keloid treatment assessment measures: A literature review

Gutierrez,

Carmichael,

Feldman

et al. 2024

JEADV Clinical Practice

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Keloids are an exaggerated response to cutaneous trauma that has both a physical and psychological burden for patients. Keloids have high recurrence rates and are monitored years after treatment. There is currently no widely accepted assessment measure specifically for keloids. The purpose of this review was to compare available assessment measures for keloids. Eleven assessment measures were assessed based on validity, reliability, limitations, parameters, technological influence and feasibility. Only two assessment measures (Detroit Keloid Scale and the Keloid Area and Severity Index) were specific for keloids, easy to use, had no cost and were suitable for longitudinal use. These measures, in conjunction with quality of life measures such as the Dermatology Life Quality Index, could be used to provide a detailed and longitudinal assessment of keloid treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Vas With Scar Rankingmentioning

confidence: 96%

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Keloid treatment assessment measures: A literature review

Gutierrez,

Carmichael,

Feldman

et al. 2024

JEADV Clinical Practice

View full text Add to dashboard Cite

show abstract

“…Before their involvement, all participants were provided with comprehensive information about the study and gave their informed consent. The Keloid Area and Severity Index (KASI) was analyzed according to previous studies [19]. The research received approval from the ethical committee of The Second Hospital of Shandong University, China, and further normal controls and patients details can be found in Supporting Information S1: Table S1.…”

Section: Methodsmentioning

confidence: 99%

BMP1 Promotes Keloid by Inducing Fibroblast Inflammation and Fibrogenesis

Wang,

Chen,

et al. 2024

J of Cellular Biochemistry

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Keloid is a typical fibrotic and inflammatory skin disease with unclear mechanisms and few therapeutic targets. In this study, we found that BMP1 was significantly increased in a collagen high‐expressing subtype of fibroblast by reanalyzing a public single‐cell RNA‐sequence data set of keloid. The number of BMP1‐positive fibroblast cells was increased in keloid fibrotic loci. Increased levels of BMP1 were further validated in the skin tissues and fibroblasts from keloid patients. Additionally, a positive correlation between BMP1 and the Keloid Area and Severity Index was found in keloid patients. In vitro analysis revealed collagen production, the phosphorylation levels of p65, and the IL‐1β secretion decreased in BMP1 interfered keloid fibroblasts. Besides, the knockdown of BMP1 inhibited the growth and migration of keloid fibroblast cells. Mechanistically, BMP1 inhibition downregulated the noncanonical TGF‐β pathways, including p‐p38 and p‐ERK1/2 signaling. Furthermore, we found the delivery of BMP1 siRNAs could significantly alleviate keloid in human keloid‐bearing nude mice. Collectively, our results indicated that BMP1 exhibited various pathogenic effects on keloids as promoting cell proliferation, migration, inflammation, and ECM deposition of fibroblast cells by regulating the noncanonical TGF‐β/p38 MAPK, and TGF‐β/ERK pathways. BMP1‐lowing strategies may appear as a potential new therapeutic target for keloid.

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Unraveling the landscape of m6A RNA methylation in wound healing and scars

Zhang,

Dong,

Gong

et al. 2024

Cell Death Discov.

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Wound healing is a complex process involving sequential stages of hemostasis, inflammation, proliferation, and remodeling. Multiple cell types and factors, including underlying conditions like diabetes and bacterial colonization, can influence healing outcomes and scar formation. N6-methyladenosine (m6A), a predominant RNA modification, plays crucial roles in gene expression regulation, impacting various biological processes and diseases. m6A regulates embryonic skin morphogenesis, wound repair, and pathophysiological processes like inflammation and angiogenesis. Recent studies have highlighted the role of m6A in wound healing, scar formation, and tissue remodeling. Additionally, m6A presents a unique expression pattern in pathological wounds and scars, potentially influencing wound healing and scar formation through modulating gene expression and cellular signaling, thereby serving as potential biomarkers or therapeutic targets. Targeting m6A modifications are potential strategies to enhance wound healing and reduce scar formation. This review aims to explore the roles and mechanisms of m6A RNA methylation in wound healing and scars, and discuss current challenges and perspectives. Continued research in this field will provide significant value for optimal wound repair and scar treatment.

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The Keloid Area and Severity Index (KASI): an objective tool for the evaluation of keloids

Cited by 4 publications

References 8 publications

Keloid treatment assessment measures: A literature review

Keloid treatment assessment measures: A literature review

BMP1 Promotes Keloid by Inducing Fibroblast Inflammation and Fibrogenesis

Unraveling the landscape of m6A RNA methylation in wound healing and scars

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