The ketogenic diet prevents steatosis and insulin resistance by reducing lipogenesis, diacylglycerol accumulation and protein kinase C activity in male rat liver

Abstract

where she earned a Master's degree conducting research on the molecular mechanisms underlying antibacterial resistance. As a PhD candidate in Dr Ceddia's lab, her current research focuses on understanding the effects of nutritional manipulation on physiological and molecular mechanisms that regulate glucose and fatty acid metabolism in skeletal muscle and liver in both males and females.

The ketogenic diet maintains insulin sensitivity and inhibits lipid accumulation in the liver

“…Jani et al. (2022) demonstrated that rats fed a KD gained significant weight and fat pad mass, and while not examined in this study, previous work shows that the high saturated fat content of a KD results in increased low density lipoproteins (Crosier & McPherson, 2022). Additionally, the specific KD used by Jani et al.…”

“…The KD and the SC diet appear to have beneficial effects with respect to liver health, as shown by the novel findings of Jani et al. (2022). This follows previous work on the KD, insulin sensitivity and hepatic steatosis (Luukkonen et al., 2020; Tendler et al., 2007).…”

“…Jani et al. (2022) showed that the KD reduced CerS6 expression compared to the HFS diet, suggesting decreased C16:0 ceramide synthesis. Similar to the CerS6‐deficient mice fed a high fat diet in the study by Turpin et al.…”

“…Therefore, the results produced by Jani et al. (2022) suggest that consuming a standard diet is as effective as the KD at managing NAFLD.…”

“…Altogether, Jani et al. (2022) exhibited the benefits of a KD with respect to NAFLD, but this specialized diet remains controversial in the literature as it may potentially impact other areas of human health.…”