The key role of targeted betacarotene supplementation on endocrine and reproductive outcomes in goats: Follicular development, ovulation rate and the GH-IGF-1 axis

Lopez-Flores, Noé M; Meza-Herrera, César A.; Galán, Carmen; Bautista-Rodriguez, D.A.; Véliz-Deras, Francisco Gerardo; Arellano-Rodriguez, G.; Peña, Cristina García-De la; Rosales-Nieto, Cesar A.; Macías‐Cruz, Ulises

doi:10.1016/j.smallrumres.2017.09.009

Cited by 7 publications

(9 citation statements)

References 30 publications

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“…Although it has not been confirmed in humans, animal research in goats [95][96][97][98] suggests that even short-term beta-carotene can enhance or modulate ovarian function and progesterone synthesis. Furthermore, beta-carotene may have endocrine-stimulating or modulating effects as shown in prepubertal goats [99][100][101], given beta-carotene supplementation compared with a control group: positive changes in blood biomarkers such as total protein [99], cholesterol [99], glucose [99], insulin [100], and triiodothyronine [101] were noted.…”

Section: Orange Foods and Reproductive Healthmentioning

confidence: 99%

A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for “Eating the Rainbow”

Minich

2019

Journal of Nutrition and Metabolism

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Over the past decades, thousands of published studies have amassed supporting recommendations to consume fruits and vegetables for physiological and psychological health. Newer research has emerged to suggest that these plant-based foods contain a plethora of not only vitamins and minerals, but perhaps, most importantly, phytonutrients. These phytonutrients have known pleiotropic effects on cellular structure and function, ultimately resulting in the modulation of protein kinases and subsequent epigenetic modification in a manner that leads to improved outcomes. Even though eating fruits and vegetables is a well-known feature of a healthy dietary pattern, population intakes continue to be below federal recommendations. To encourage consumers to include fruits and vegetables into their diet, an “eat by color” approach is proposed in this review. Although each individual food may have numerous effects based on its constituents, the goal of this simplified approach was to identify general patterns of benefits based on the preponderance of scientific data and known mechanisms of food-based constituents. It is suggested that such a consumer-oriented categorization of these plant-based foods may lead to greater recognition of their importance in the daily diet throughout the lifespan. Other adjunctive strategies to heighten awareness of fruits and vegetables are discussed.

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Section: Orange Foods and Reproductive Healthmentioning

confidence: 99%

A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for “Eating the Rainbow”

Minich

2019

Journal of Nutrition and Metabolism

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“…Additionally, high concentration of β-carotene in corpora lutea is reported to promote ovarian steroidogenesis and increases plasma progesterone concentration in goats and cats (Weng et al, 2000;Arellano-Rodriguez et al, 2009;Meza-Herrera et al, 2013a). Studies have reported the positive effect of β-carotene on the response to oestrus, improved ovulation rate and conception rate in cattle and goats (Aréchiga et al, 1998;de Ondarza et al, 2009;Arellano-Rodriguez et al, 2007;Meza-Herrera et al, 2013b;López-Flores et al, 2018). However, other studies have refuted the positive effect of β-carotene on ovarian activity and fertility.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the conflicting results and limited studies in goats concerning β-carotene effect on reproduction, more studies are necessary in order to ascertain its effects on reproduction. Concerning few studies in goats, β-carotene supplementation improved follicular development, ovulation rate and progesterone production (Arellano-Rodriguez et al, 2009;Meza-Herrera et al, 2013b;López-Flores et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

β-carotene Supplementation Increases Progesterone Concentration and Glutathione Peroxidase Activity Following Alternative Progesterone Primed Oestrous Synchronization Protocol in Goats

Gore¹,

Lehloenya²

2020

American Journal of Animal and Veterinary Sciences

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The present study evaluated the effect of β-carotene supplementation and oestrous synchronization protocol on ovarian activity and fertility of Saanen does during the breeding season. The supplemented group received 100 mg β-carotene during the breeding and all does were synchronised with Controlled Internal Drug Release dispenser (CIDR) and injected with cloprostenol at CIDR withdrawal. One group of does were injected with 300 IU of eCG, while in another group bucks wearing aprons were introduced at CIDR withdrawal. Does were artificially inseminated twice (48 and 60 h) with fresh undiluted semen. The onset and duration of oestrus, progesterone, oestrdiol-17β and glutathione peroxidase activity, oestrous response and conception rate were analysed. Synchronization protocol did not affect response to oestrus, onset and duration of oestrus and oestradiol-17β concentration. The male presence group had significantly higher conception rate (97%) than the eCG (72%) group. βcarotene supplemented group had higher progesterone concentration and glutathione peroxidase activity. Supplemental β-carotene during the breeding period therefore, could play an important role on establishment of pregnancy due to high progesterone concentration and glutathione peroxidase activity. Inclusion of male effect in progesterone based oestrous synchronization protocol improves conception rate. Therefore, male effect can be used as an alternative to equine chorionic gonadotropin in progesterone based oestrous synchronization protocols especially, where drugs for oestrous synchronization are not affordable.

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“…While BETA-supply has demonstrated to protect both cells and cellular components against oxygen free radicals through its antioxidant function [3], it has been proposed that BETA is able to act independently as vitamin-A precursor [4]. Nonetheless, inconsistent results regarding the effect of BETA-supplementation upon reproductive function have been described, with negative effects [5], positive effects [6] and even no effects [7]. From a reproductive stand point, BETA-supplementation has been associated with increased steroidogenesis in both the corpus luteum and the follicular tissue [6,[8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, nutritional supplementation with a mixture of BETA, polyphenolic compounds, and probiotics demonstrated to up-regulate genes involved in both the activation of cellular gonadotropes and up-regulation of GnRH genes [23]. While the involvement nutritional supplementation as a modulator of the HPG axis has been proposed [8][9][10][11][12][13][14][15][16]20,[23][24][25], previous studies of our group have demonstrated an interesting role of BETA as a modulator not only of serum insulin [18], triiodothyronine [26], as well as the GH-IGF-1 system [6] but also upon some selected blood metabolites [27]. Building on these previous findings, we hypothesized an out-of-season positive effect of BETA supply on both ovarian function and the releasing pattern of LH across time in yearling goats; this study attempts to solve such inquires.…”

Section: Introductionmentioning

confidence: 99%

Precision Betacarotene Supplementation Enhanced Ovarian Function and the LH Release Pattern in Yearling Crossbred Anestrous Goats

Lopez-Flores

Meza-Herrera

Marı́n

et al. 2020

Animals

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The possible out-of-season effect of beta-carotene supplementation on ovulation rate (OR), antral follicles (AFN), and total ovarian activity (TOA = OR + AFN) as related to the LH release pattern in yearling anestrous goats was evaluated. In late April, Alpine-Saanen-Nubian x Criollo goats (n = 22, 26 N) were randomly allotted to: (1) Beta-carotene (BETA; n = 10, orally supplemented with 50 mg/goat/d; 36.4 ± 1.07 kg live weight (LW), 3.5 ± 0.20 units, body condition score (BCS) or (2) Non-supplemented (CONT; n = 12, 35.2 ± 1.07 kg LW, 3.4 ± 0.2 units BCS). Upon estrus synchronization, an intensive blood sampling (6 h × 15 min) was accomplished in May for LH quantifications; response variables included (pulsatility-PULSE, time to first pulse-TTFP, amplitude-AMPL, nadir-NAD and area under the curve-AUC). Thereafter, an ultrasonography scanning was completed to assess OR and AFN. The Munro algorithm was used to quantify LH pulsatility; if significant effects of time, treatment or interaction were identified, data were compared across time. Neither LW nor BCS (p > 0.05) or even the LH (p > 0.05); PULSE (4.1 ± 0.9 pulses/6 h), NAD (0.47 ± 0.13 ng) and AUC (51.7 ± 18.6 units) differed between treatments. Nonetheless, OR (1.57 vs. 0.87 ± 0.18 units) and TOA (3.44 vs. 1.87 ± 0.45 units) escorted by a reduced TTFP (33 vs. 126 ± 31.9 min) and an increased AMPL (0.55 vs. 0.24 ± 0.9 ng), favored to the BETA supplemented group (p < 0.05), possibly through a GnRH-LH enhanced pathway and(or) a direct effect at ovarian level. Results are relevant to speed-up the out-of-season reproductive outcomes in goats while may embrace translational applications.

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The key role of targeted betacarotene supplementation on endocrine and reproductive outcomes in goats: Follicular development, ovulation rate and the GH-IGF-1 axis

Cited by 7 publications

References 30 publications

A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for “Eating the Rainbow”

A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for “Eating the Rainbow”

β-carotene Supplementation Increases Progesterone Concentration and Glutathione Peroxidase Activity Following Alternative Progesterone Primed Oestrous Synchronization Protocol in Goats

Precision Betacarotene Supplementation Enhanced Ovarian Function and the LH Release Pattern in Yearling Crossbred Anestrous Goats

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