The kidneys play an important role in the clearance of rFVIIa in rats

Vestergaard, Bill; Appa, Rupa Shree; Lykkesfeldt, Jens; Agersø, Henrik

doi:10.1016/j.thromres.2014.03.034

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…Importantly, EPCR does not seem to modulate the clearance of FVIIa , whereas the asialoglycoprotein receptor is probably involved in the clearance of FVIIa molecules that are hyposialylated . Regarding the cubilin/megalin receptor, this complex is known to be involved in the recovery of proteins in the renal system . It seems possible that this receptor complex contributes to the uptake and the degradation of both FVIIa and FVIIa associated with antithrombin in the kidneys.…”

Section: Discussionmentioning

confidence: 99%

LDL receptor‐related protein 1 contributes to the clearance of the activated factor VII–antithrombin complex

Fazavana

Muczynski

Proulle

et al. 2016

Journal of Thrombosis and Haemostasis

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To cite this article: Fazavana JG, Muczynski V, Proulle V, Wohner N, Christophe OD, Lenting PJ, Denis CV. LDL receptor-related protein 1 contributes to the clearance of the activated factor VII-antithrombin complex. J Thromb Haemost 2016; 14: 2458-70. Essentials• Factor VIIa is cleared principally as a complex with antithrombin.• Enzyme/serpin complexes are preferred ligands for the scavenger-receptor LRP1.• Factor VIIa/antithrombin but not factor VIIa alone is a ligand for LRP1.• Macrophage-expressed LRP1 contributes to the clearance of factor VIIa/antithrombin.

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Section: Discussionmentioning

confidence: 99%