2014
DOI: 10.1016/j.ejcb.2014.07.007
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The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors

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Cited by 36 publications
(42 citation statements)
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“…We show that KIF21B is highly processive, and together with its known function in MT-dependent transport (Labonte et al, 2014), also identify a role for KIF21B in regulating MT dynamics. Thus, similar to other kinesin-4 family members (Drummond, 2011; Walczak et al, 2013), KIF21B exerts dual functions as a processive motor and MT regulator.…”
Section: Discussionmentioning
confidence: 74%
See 1 more Smart Citation
“…We show that KIF21B is highly processive, and together with its known function in MT-dependent transport (Labonte et al, 2014), also identify a role for KIF21B in regulating MT dynamics. Thus, similar to other kinesin-4 family members (Drummond, 2011; Walczak et al, 2013), KIF21B exerts dual functions as a processive motor and MT regulator.…”
Section: Discussionmentioning
confidence: 74%
“…Within neurons, KIF21B is present in axons and dendrites, with particular enrichment in growth cones of developing neurons (Huang and Banker, 2012; Marszalek et al, 1999). KIF21B binds E3 ubiquitin ligase TRIM3 (tripartite motif protein 3) to regulate GABA A receptor surface delivery (Labonte et al, 2014; Labonte et al, 2013). Micro-duplications in the chromosomal region 1q32.1, including the Kif21b gene, have been described in individuals with delayed motor and cognitive development (Olson et al, 2012).…”
Section: Introductionmentioning
confidence: 99%
“…ATG8s were originally implicated in membrane trafficking processes 53 . GABARAP family members facilitate transport of vesicular structures along microtubules 54, 55 to the plasma membrane, and here mediate the fusion of these vesicles with the plasma membrane 5658 . Anticipating that GABARAPs are involved in the trafficking of Nef to the plasma membrane, we investigated whether Nef localizes with the GABARAPs in vesicular structures and whether expression of Nef and the ATG8 proteins lead to changes in their distribution patterns when compared with that of the patterns obtained for the individual factors.…”
Section: Resultsmentioning
confidence: 99%
“…Furthermore, it has been demonstrated that KIF21B binds to the ubiquitin E3 ligase TRIM3, which can modulate the function of KIF21B (Labonté et al, 2013). The motor was also implicated in the surface delivery of GABA A receptors in neurons, but the interaction is likely indirect (Labonté et al, 2014). …”
Section: Introductionmentioning
confidence: 99%