The Kinetics of De-agglomeration of Magnesium Stearate Dry-Coated Salbutamol Sulphate Powders

Shi, Jiani; Das, Shyamal C.; Morton, David Alexander Vodden; Stewart, Peter

doi:10.14356/kona.2015001

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…The work aims to provide a complete and comprehensive study of the differences in surface properties between the different solid forms of quercetin. Understanding the surface chemistry of crystalline solids and controlling it via crystal engineering approaches (e.g., choice of appropriate crystal structure, control of crystal morphology) can lead to a rational and quicker particulate product and process design. − …”

Section: Introductionmentioning

confidence: 99%

Relating Crystal Structure to Surface Properties: A Study on Quercetin Solid Forms

Klitou

Rosbottom

Karde

et al. 2022

Crystal Growth & Design

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The surface energy and surface chemistry of a crystal are of great importance when designing particles for a specific application, as these will impact both downstream manufacturing processes as well as final product quality. In this work, the surface properties of two different quercetin solvates (quercetin dihydrate and quercetin DMSO solvate) were studied using molecular (synthonic) modeling and experimental techniques, including inverse gas chromatography (IGC) and contact angle measurements, to establish a relationship between crystal structure and surface properties. The attachment energy model was used to predict morphologies and calculate surface properties through the study of their growth synthons. The modeling results confirmed the surface chemistry anisotropy for the two forms. For quercetin dihydrate, the {010} facets were found to grow mainly by nonpolar offset quercetin–quercetin stacking interactions, thus being hydrophobic, while the {100} facets were expected to be hydrophilic, growing by a polar quercetin–water hydrogen bond. For QDMSO, the dominant facet {002} grows by a strong polar quercetin–quercetin hydrogen bonding interaction, while the second most dominant facet {011} grows by nonpolar π–π stacking interactions. Water contact angle measurements and IGC confirmed a greater overall surface hydrophilicity for QDMSO compared to QDH and demonstrated surface energy heterogeneity for both structures. This work shows how synthonic modeling can help in the prediction of the surface nature of crystalline particles and guide the choice of parameters that will determine the optimal crystal form and final morphology for targeted surface properties, for example, the choice of crystallization conditions, choice of solvent, or presence of additives or impurities, which can direct the crystallization of a specific crystal form or crystal shape.

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Section: Introductionmentioning

confidence: 99%

Relating Crystal Structure to Surface Properties: A Study on Quercetin Solid Forms

Klitou

Rosbottom

Karde

et al. 2022

Crystal Growth & Design

View full text Add to dashboard Cite

show abstract

“…Real time aerosolisation characterisation of dry coated powders using laser diffraction systems has also been used to investigate optimum coating percentage of magnesium stearate guest particles over salbutamol sulphate host particles. 2% magnesium stearate was calculated as the optimum percentage for dry coating that resulted in de-agglomeration of cohesive agglomerates causing improved aerosolisation [70].…”

Section: Particle Size Analysis/ Aerosizermentioning

confidence: 99%

Characterisation and surface-profiling techniques for composite particles produced by dry powder coating in pharmaceutical drug delivery

Dahmash

Mohammed

2016

Drug Discovery Today

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The production of composite particles using dry powder coating is a one-step, environmentally friendly, process for the fabrication of particles with targeted properties and favourable functionalities. Diverse functionalities, such flowability enhancement, content uniformity, and dissolution, can be developed from dry particle coating. In this review, we discuss the particle functionalities that can be tailored and the selection of characterisation techniques relevant to understanding their molecular basis. We address key features in the powder blend sampling process and explore the relevant characterisation techniques, focussing on the functionality delivered by dry coating and on surface profiling that explores the dynamics and surface characteristics of the composite blends.

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“…Powders consist of large collections of solid particles. In subjecting a powder to the various analytical tests utilized for physical characterization, it is important to keep track what aspect of the particles is being interrogated by the analytical method used (Crowder T. and Hickey A., 2000;Feeley J. et al, 1998;Hickey A. et al, 2003;Shi J. et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…The BET analysis on the other hand, provides information about the surface ability to interact with the gas adsorbate, but reveals nothing about the inner core of the particles. Needless to say, full physical characterization of powders requires understanding both surface-and core-particle properties (Feeley J. et al, 1998;Ho R. et al, 2009;Otte A. and Carvajal T., 2011;Shi J. et al, 2015;Willart J. et al, 2006). Accordingly, both sets of properties are equally important.…”

Section: Introductionmentioning

confidence: 99%

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Integrating Particle Microstructure, Surface and Mechanical Characterization with Bulk Powder Processing

Pinal

Carvajal

2020

KONA

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Multiple industrial applications, including pharmaceuticals, rely on the processing of powders. The current powder characterization framework is fragmented into two general areas. One deals with understanding powders from the standpoint of its constituting agents-particles. The other deals with understanding based on the bulkthe collective behavior of particles. While complementary, the two aspects provide distinct pieces of information. Whenever possible, experimental techniques should be used to predict powder behavior. However, it is equally important to recognize that because of the natural complexity of powders, existing predictive approaches will continue to be of limited success for predicting the collective behavior of particles. This article discusses the understanding of powder properties from two perspectives. One is the effect of surface energy at the bulk level (large collections of particles), which controls interactions between powders. This aspect is most useful if studied at the bulk-powder level, not at the single-particle level. Another perspective deals with the physico-mechanical properties of individual particles, responsible for the observed behavior of powders when subjected to mechanical stress from unit operations such as milling. This aspect, which controls the failure mechanism of powders subjected to milling, is most useful if assessed at the single-particle, not at the bulk level. Therefore, in order to fully understand, and eventually predict, or at least effectively model powder behavior, a good-judgement-based combination of microscopic and bulk-level analytical methods is necessary.

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The Kinetics of De-agglomeration of Magnesium Stearate Dry-Coated Salbutamol Sulphate Powders

Cited by 4 publications

References 29 publications

Relating Crystal Structure to Surface Properties: A Study on Quercetin Solid Forms

Relating Crystal Structure to Surface Properties: A Study on Quercetin Solid Forms

Characterisation and surface-profiling techniques for composite particles produced by dry powder coating in pharmaceutical drug delivery

Integrating Particle Microstructure, Surface and Mechanical Characterization with Bulk Powder Processing

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