The kinetics of dissolution for a non-disintegrating standard substrate

Abstract

The dissolution profiles for a 1 cm sodium chloride cube, which was considered to represent a standard non‐distintegrating substrate, were obtained in seven kinds of dissolution apparatus. The results were used to assess experimental reproducibility and apparatus variables and to examine the adherence of the kinetics of the dissolution process to theoretical rate laws.

System for Automated Determination of Dissolution Rate

“…At a speed of 100 rpm in 0.1 N HCI, no such differences were observed. Withey (8) observed wide variations when dissolving a single sodium chloride crystal a t an agitation speed of 50 rpm. The large coefficient of variation reported reflects the nondisintegrating nature of the sample and the small percentage of sodium chloride dissolved a t the low agitation speed of 50 rpm and illustrates the importance of selecting the proper speed for each dosage form based on correlations with in uiuo data.…”

Tableting Research and Technology

“…sodium chloride cube to represent a standard nondisintegrating substrate, Withey (398) compared the dissolution profiles in seven types of apparatus. By eliminating dissolution variables due to the substrate itself, differences in agitation intensity in the different apparatus could be assessed.…”

Dissolution Kinetics of Single Crystals of a-Lactose Monohydrate

“…Dissolution kinetic models have been developed for multiparticulate systems and single particles. [2][3][4][5][6] There are two factors that are often neglected in the development of the model: the shape factor of the component particles and the anisotropy of the dissolution process. The importance of shape factor has been discussed for tablets 2,3 and recently demonstrated for salicylic acid.…”