“…Such biphasic plots can have different reasons, for instance: the presence of one carrier plus a first order process (Fuhrmann and Völker, 1993;Maier et al, 2002), the presence of more than one carrier (Coons et al, 1995), a change in the kinetic parameters of a carrier caused by membrane energization (Miller and Harun, 1978) or ligand binding (Sanders, 1986), an inhibition of glucose uptake by glucose-6-phosphate (Rizzi et al, 1996), or the distribution of the transported substance between more than one subcellular compartments (Slayman et al, 1994).…”