The kisspeptin system in and beyond reproduction: exploring intricate pathways and potential links between endometriosis and polycystic ovary syndrome

Salmeri, Noemi; Viganò, Paola; Cavoretto, Paolo; Marci, Roberto; Candiani, Massimo

doi:10.1007/s11154-023-09826-0

Cited by 21 publications

(8 citation statements)

References 174 publications

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“…In recent years, there have been a number of well-designed interdisciplinary observational studies reporting the molecular mechanisms 43 , 44 , 45 and systemic impacts 46 , 47 associated with the onset and progression of endometriosis. The potential models and mediators include the genetic/epigenetic theory, 47 , 48 , 49 the neuroendocrine peptide kisspeptin system, 50 blood metabolites, 51 circulatory proteins, 52 , 53 systemic inflammatory mediators and molecules. 36 While the number of relevant clinical interventional studies is currently limited, cutting-edge trials are continuously emerging, actively progressing, and additional findings may subsequently be translated into clinical applications in the future.…”

Section: Discussionmentioning

confidence: 99%

An overview and comprehensive analysis of interdisciplinary clinical research in endometriosis based on trial registry

Xu,

Deng,

Fei

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 99%

An overview and comprehensive analysis of interdisciplinary clinical research in endometriosis based on trial registry

Xu,

Deng,

Fei

et al. 2024

iScience

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“…Not considering genetic aspects is a limitation of this study and is recommended for future studies. Also, reproductive dysfunction and endometriosis can be linked to important mediating factors of leptin 64 , 65 , hypothalamic-pituitary-gonadal hormonal pathways (HPA), kisspeptin [66] , insulin and insulin like growth factor-1(IGF-1) [67] which can be affected differently by various exercise; not measuring them were other limitations of this study and are recommended to be considered in future studies.…”

Section: Discussionmentioning

confidence: 99%

The effect of pentoxifylline and different types of exercise training on coagulation factors in a rat endometriosis model

Salehpoor,

Rezapourmoghadam,

Tanideh

et al. 2024

European Journal of Obstetrics & Gynecology and Reproductiv

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“…The 5-HT molecular pathway is known to play a pivotal role in numerous biological mechanisms, including chronic pelvic pain in endometriosis [69]. In this context, 5-HT has been linked to a range of other neurotransmitters [70]. This observation is especially noteworthy considering that endometriosis is associated with an increased risk of placental defects [71].…”

Section: Discussionmentioning

confidence: 99%

The S/S Genotype of the 5-HTTLPR (Serotonin-Transporter-Linked Promoter Region) Variant of the SLC6A4 Gene Decreases the Risk of Pre-Eclampsia

Ramírez-Armas,

Garza-Veloz,

Olivas-Chávez

et al. 2023

JPM

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Pre-eclampsia (PE) is a disorder characterized by hypertension in the second trimester of pregnancy that results from abnormal placentation affecting fetal development and maternal health. Previous studies have shown the role of serotonin (5-HT) that leads to poor placental perfusion, where S/S and S/L polymorphisms promote the solute carrier family 6 member 4 (SLC6A4) gene associated with the risk of developing changes in the microvasculature of the placenta. This study looked at the association between the gene variant 5-HTTLPR (serotonin-transporter-linked promoter region) of the SLC6A4 gene and the occurrence of PE. A total of 200 women were included: 100 cases (pregnant with PE) and 100 controls (pregnant without complications). Genotyping of the 5-HTTLPR variant was performed using polymerase chain reaction (PCR). Associations between the presence of the genetic variant of interest and PE and other clinical features were evaluated statistically. The frequencies of S/S, S/L, and L/L genotypes were 32%, 53%, and 15% for the cases and 55%, 25%, and 20% in the control group. Compared to the controls, the genotype frequencies S/S vs. S/L + L/L (recessive model) in the cases group were different (p = 0.002). The S/S genotype decreased the probability of PE (OR = 0.39, 95% IC: 0.22–0.69, p = 0.002) and PE with severity criteria (OR = 0.39, 95% IC: 0.17–0.91, p = 0.045). The 5-HTTLPR gene variant of the SLC6A4 gene modifies the risk of PE development among the studied population.

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The kisspeptin system in and beyond reproduction: exploring intricate pathways and potential links between endometriosis and polycystic ovary syndrome

Cited by 21 publications

References 174 publications

An overview and comprehensive analysis of interdisciplinary clinical research in endometriosis based on trial registry

An overview and comprehensive analysis of interdisciplinary clinical research in endometriosis based on trial registry

The effect of pentoxifylline and different types of exercise training on coagulation factors in a rat endometriosis model

The S/S Genotype of the 5-HTTLPR (Serotonin-Transporter-Linked Promoter Region) Variant of the SLC6A4 Gene Decreases the Risk of Pre-Eclampsia

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