The kruppel-like factor (KLF) family, diseases, and physiological events

Yuce, Kemal; Ozkan, Ahmet Ismail

doi:10.1016/j.gene.2023.148027

Cited by 20 publications

(5 citation statements)

References 241 publications

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“…The KLF family of transcription factors are zinc finger proteins consisting of 18 members and are responsible for activation and repression of transcription; particularly, several members have been linked to specific processes such as KLF-4, -5, -10, -13, -14, and -15, which relate to the cardiovascular system. In addition, KLF-4 and -7 relate to diabetes, while dysregulation of others further contributes to CVDs [4,31].…”

Section: Discussionmentioning

confidence: 99%

Is the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Krüppel-like Family of Transcription Factors

García-Loredo,

Santoyo-Suarez,

Rodríguez-Nuñez

et al. 2024

Life

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The CACCC-box motif emerges as a pivotal cis-regulatory element implicated in diverse developmental processes and diseases, particularly cardiovascular diseases (CVDs). This study centers on the intricate interplay between the CACCC-box and its binding proteins such as: the Krüppel-Like Family (KLF) of transcription factors as primary effectors in the context of CVDs. Our analysis was through a bioinformatics approach, which revealed significant transcriptional activity among KLF subgroup 2, exhibiting the highest number of interactions focusing on the established roles: pluripotency, cancer, and cardiovascular development and diseases. Our analysis reveals KLF’s interactions with GATA4, MEF2C, NKX2.5 and other ~90 potential genes that participate in the regulation of the hypertrophic environment (or CVDs’ Environment). Also, the GO analysis showed that genes containing the motif CACCC were enriched for multiple CVDs; in combination with STRING analysis, these results pointed to a link between KLFs and these diseases. The analysis further identifies other potential CACCC-box binding factors, such as SP family members, WT1, VEZF1, and -SALL4, which are implicated in cardiac contraction, remodeling, and inflammation processes.

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Section: Discussionmentioning

confidence: 99%

Is the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Krüppel-like Family of Transcription Factors

García-Loredo,

Santoyo-Suarez,

Rodríguez-Nuñez

et al. 2024

Life

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“…Krüppel family zinc-finger proteins are an evolutionarily conserved family of transcription factors that play a pivotal role in development, physiology, and stem cell regulation across metazoan species 21,22 . Drosophila Krüppel (Kr), a founding member of this family, was first identified as a gap gene during embryonic development 23 .…”

Section: Introductionmentioning

confidence: 99%

The Conserved Transcription Factor Krüppel Regulates the Survival and Neurogenesis of Mushroom Body Neuroblasts inDrosophilaAdult Brains

Man,

Shu,

Shi

et al. 2024

Preprint

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SummaryIn various metazoans, includingDrosophilaand humans, neural progenitors exit the cell cycle and are eliminated by the end of development, limiting adult neurogenesis. We demonstrate that inDrosophila,the conserved transcription factorKrüppel(Kr) controls neurogenic capacity of a specific subset of neuroblasts that forms the mushroom body (MBNBs), analogous to the mammalian hippocampus. TheIrregular facetmutation, which altersKrexpression, and neuroblast-specific Kr depletion allow MBNBs, but not other neuroblasts, to persist beyond development and generate neurons in adult brains. Persisting MBNBs express Imp, an RNA-binding protein that promotes neuroblast proliferation and survival. Our results underscore a critical role for Kr in the developmental control of a specific progenitor population, uncovering a novel mechanism controlling adult neurogenesis.

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“…Krüppel‐like factor 14 (KLF14) is a member of the zinc‐finger‐containing transcription factor family, known for its pivotal role in regulating diverse biological processes including cell growth, survival, proliferation, and differentiation 1,2 . This group comprises 18 KLF proteins, organized into three separate families 1 .…”

Section: Introductionmentioning

confidence: 99%

“…This group comprises 18 KLF proteins, organized into three separate families 1 . Several members of the KLF family impact the differentiation and function of immune system cells 2–7 . Physiological stimuli and various cytokines are responsible for regulating KLF expression 2,7 …”

Section: Introductionmentioning

confidence: 99%

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Association of KLF14 rs4731702 gene polymorphism with metabolic phenotype in young patients with type 1 diabetes

Ryba‐Stanisławowska,

Słomiński,

Myśliwiec

2024

Diabetes Obesity Metabolism

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AimTo explore the potential association between the KLF14 rs4731702 polymorphism and metabolic syndrome traits among patients diagnosed with type 1 diabetes (T1D).MethodsThe study group included 350 patients with T1D and 250 healthy control subjects. The analysis focused on the genotyping of KLF14 rs4731702 single nucleotide polymorphism (SNP), as well as evaluating serum concentrations of inflammatory markers, blood pressure, lipid profiles, and the quantitative status of CD4 + CD25highFOXP3+ T cells.ResultsPatients with T1D carrying the T allele of KLF14 rs4731702 SNP had higher high‐density lipoprotein cholesterol, lower low‐density lipoprotein cholesterol, as well as lower glycated haemoglobin and serum concentration of proinflammatory markers than C allele carriers. They also developed hypertension less often than carriers of the C allele. The analysis of CD4 + CD25highFOXP3+ regulatory T‐cell status based on KLF14 genotype showed that, in T1D patients, those with the TT genotype had the highest frequency of these cells compared to carriers of the CC and CT genotypes.ConclusionOur study suggests that the T allele of the KLF14 rs4731702 SNP might confer a protective effect against the development of obesity, hypertension, dyslipidaemia, and chronic inflammatory state in patients diagnosed with T1D.

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The kruppel-like factor (KLF) family, diseases, and physiological events

Cited by 20 publications

References 241 publications

Is the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Krüppel-like Family of Transcription Factors

Is the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Krüppel-like Family of Transcription Factors

The Conserved Transcription Factor Krüppel Regulates the Survival and Neurogenesis of Mushroom Body Neuroblasts inDrosophilaAdult Brains

Association of KLF14 rs4731702 gene polymorphism with metabolic phenotype in young patients with type 1 diabetes

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