The lack of association between components of metabolic syndrome and treatment resistance in depression

Šagud, Marina; Mihaljević-Peleš, Alma; Uzun, Suzana; Ćusa, Bjanka Vuksan; Kozumplik, Oliver; Kudlek-Mikulic, Suzan; Mustapić, Maja; Barišić, Ivan; Mück‐Šeler, Dorotea; Pivac, Nela

doi:10.1007/s00213-013-3085-x

Cited by 25 publications

(45 citation statements)

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“…Three papers in this issue extend this to address aspects of metabolic function in patients with mental disorders (Amrami-Weizman et al 2013;Sagud et al 2013;Hu et al 2013). The first finding, little remarked upon by Sagud et al in their paper (Sagud et al 2013), is that metabolic syndrome is common in major depressive disorder: seen in about one third of patients in comparison to about one fifth of the general population (Beltran-Sanchez et al 2013). This is so common as to suggest we should routinely be evaluating this in our patients with major depression.…”

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confidence: 99%

“…Over the last year or so, a number of papers in Psychopharmacology have examined the effects of psychotropic drugs on metabolic function and other aspects of physical health (Yan et al 2013;Amrami-Weizman et al 2013;Vieweg et al 2013;Konopaske et al 2013;Joshi et al 2013;Santarelli et al 2013;Kiyatkin 2013;Ou et al 2013;Ogasa et al 2013;Davey et al 2012;Jassim et al 2012;Kim et al 2013). Three papers in this issue extend this to address aspects of metabolic function in patients with mental disorders (Amrami-Weizman et al 2013;Sagud et al 2013;Hu et al 2013). The first finding, little remarked upon by Sagud et al in their paper (Sagud et al 2013), is that metabolic syndrome is common in major depressive disorder: seen in about one third of patients in comparison to about one fifth of the general population (Beltran-Sanchez et al 2013).…”

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confidence: 99%

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Mind the mortality gap: the importance of metabolic function in mental illnesses

Howes

Beck

2013

Psychopharmacology

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confidence: 99%

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Mind the mortality gap: the importance of metabolic function in mental illnesses

Howes

Beck

2013

Psychopharmacology

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“…In particular the following features have been acknowledged in medical scientific literature as characteristic of TRD and have been found in chronically depressed individuals treated in tertiary care: greater number of episodes of depression (Dudek, et al, 2010;Sagud, et al, 2013), greater severity of depression (Souery, et al, 2007); higher levels of medical and psychiatric comorbidity (Souery, et al, 2007;Amital, et al, 2013); greater traumatic load (Amital, et al, 2013;Kaplan & Klientob, 2000); higher levels of disability (Amital, et al, 2013;Petersen, et al, 2004);…”

Section: Discussionmentioning

confidence: 99%

“…and are more likely to attempt suicide (Sagud, et al, 2013;Souery, et al, 2007;Pfeiffer, Kim, Ganoczy, Zivin & Valenstein, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Although relatively few studies have examined the psychological and psychosocial factors associated with TRD, treatment resistance in depression has been linked to an earlier age of onset (Dudek, et al, 2010;Souery, et al, 2007), more frequent (Dudek, et al, 2010;Sagud, et al, 2013) and recurrent (Souery, et al, 2007) episodes of depression, longer duration of illness (Sagud, et al, 2013), greater severity of depression (Souery, et al, 2007) and an older current age (Sagud, et al, 2013). Patients with TRD are also more likely to be hospitalised for treatment (Souery, et al, 2007) and to have a greater risk of suicide (Sagud, et al, 2013;Souery, et al, 2007;Pfeiffer, Kim, Ganoczy, Zivin & Valenstein, 2013).…”

Section: Psychological and Psychosocial Correlatesmentioning

confidence: 99%

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Chronic and treatment-resistant depression

Murphy¹

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Major Depression does not always remit even with appropriate treatment, and unremitting or difficult-to-treat depression is thought to contribute to the large disease burden caused by depression. Difficult-to-treat depression is an overarching term that can be used to describe depression which is chronic, unremitting or treatment-resistant. The concept of difficult-to-treat depression and the terms used to describe it have not been well validated or universally adopted for use in research and clinical practice. Accordingly, the overarching aim of this thesis was to investigate difficult-to-treat depression, including its conceptualisation and its correlates, with a particular focus on chronic and treatment-resistant depression (TRD). Three methodological approaches were employed to examine this complex phenomenon: 1) a systematic review of the literature; 2) analysis of epidemiological data; and 3) analysis of clinical data. found to have a lifetime prevalence of 4.6% (95% CI: 3.9 -5.3%) and was found to be present in 29.4% (95% CI: 25.6 -33.3%) of community-residing individuals with a lifetime depressive disorder. Higher rates of psychiatric co-morbidity (OR = 1.42; 95% CI = 1.26-1.61), older current age (OR = 1.04; 95% CI = 1.02-1.05), a younger age of onset (OR = .97; 95% CI = .95-.98) and more frequent episodes of depression (OR = 1.75; 95% CI = 1.07-2.86) were significant correlates of chronic depression. Differences in health service utilisation associated with chronic depression were assessed to determine whether chronic depression treated in the tertiary care sector was likely to represent TRD. Survey respondents with chronic depression who were treated in tertiary care settings had more complex presentations and many of the clinical features previously associated with TRD, including higher levels of medical and psychiatric co-morbidity, greater traumatic load, higher levels of disability, greater symptom severity and greater risk of attempting suicide. iv The findings from the NSMHWB suggested that those whose chronic depression is treated in tertiary care settings may be less responsive to treatment, thus indicating likely TRD. In order to assess the degree of TRD in patients seen in tertiary care settings a sample of depressed inpatients (N = 70) was recruited. The majority of these depressed inpatients had a chronic illness trajectory (N = 64; 91.4%) and had a moderate to high level of TRD as determined by the five existing staging models of TRD. Each of the five staging models of TRD was highly correlated with the other four models, suggesting a substantial degree of agreement between models on their ratings of TRD. An omnibus measure of TRD (M = 0; SD = 4.5) was created by combining the five TRD models into one composite index. Using this composite index as the outcome variable, the following covariates were found to be associated with higher levels of TRD: higher prevalence of suicide attempts (β = 1.71, t(11) = 3.62, p < .001), older current age (β = 14, t(11) = 2.92, p < .005), earlier a...

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Socio-demographic and clinical predictors of treatment resistant depression: A prospective European multicenter study

Balestri

Calati

Souery

et al. 2016

Journal of Affective Disorders

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The lack of association between components of metabolic syndrome and treatment resistance in depression

Cited by 25 publications

References 30 publications

Mind the mortality gap: the importance of metabolic function in mental illnesses

Mind the mortality gap: the importance of metabolic function in mental illnesses

Chronic and treatment-resistant depression

Socio-demographic and clinical predictors of treatment resistant depression: A prospective European multicenter study

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