The Lack of Secreted IgA Spontaneously Induces the Mucosal Inflammation Specifically in the Ileum

Watabe, Taro; Nagaishi, Takashi; Hosoya, Akinori; Jose, Nisha; Tokai, Arisa; Kojima, Yudai; Adachi, Takahiro; Watanabe, Mamoru

doi:10.1016/s0016-5085(17)33406-6

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2019

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 1980s, Watabe et al [19] studies confirmed that IgA mediated response depends on the help of T lymphocytes, and the participation of cytokines is also required. IL-2 is one of the T lymphocyte growth factors.…”

Section: Discussionmentioning

confidence: 99%

Yaşlı Farelerde Bağırsak Mukozası Bağışıklığına β-Kazomorfin-7’nin Etkisi

Yin¹,

Liu²,

Yang³

et al. 2019

Kafkas Univ Vet Fak Derg

View full text Add to dashboard Cite

The immune deficiency caused by aging deserves attention, especially the weakening of intestinal mucosal immunity. The effect of β-casomorphin-7 on intestinal mucosal immunity was investigated in aged mice. Mice were treated without or with different doses of β-casomorphin-7 for 30 days. Histopathological studies showed the tissue protective role of β-casomorphin-7 in aged mice. Lowdose group could significantly increase the level of IL-2 and TNF-α in intestinal mucosa. A significant increase in the level of SIgA was observed in medium-and high-dose groups. The low and medium dose groups could significantly increase the activity of SOD in small intestine mucosa. All dose groups significantly reduced the levels of MDA. The results suggest that β-casomorphin-7 could improve intestinal mucosal immune decline which is induced by aging The mechanisms for the regulating effects were likely through balancing the cytokine level and controlling the oxidative stress.

show abstract

Section: Discussionmentioning

confidence: 99%