The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications

Abstract

Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers.

The viral etiology of EBV-associated gastric cancers contributes to their unique pathology, clinical outcomes, treatment responses and immune landscape

“…Long non-coding RNAs are defined as RNAs over 200 nucleotides long and lack protein-coding abilities ( 117 ). Both EBV and their host cells are known to produce a number of lncRNAs ( 89 , 117 , 118 ).…”

“…Long non-coding RNAs are defined as RNAs over 200 nucleotides long and lack protein-coding abilities ( 117 ). Both EBV and their host cells are known to produce a number of lncRNAs ( 89 , 117 , 118 ). In particular, several host cell lncRNAs are differentially expressed in EBVaGC, including small nucleolar RNA host gene 8 (SNHG8), which modulate the expression of a number of cellular and viral genes, as well induces cellular proliferation and invasion ( 119 , 120 ).…”