2015
DOI: 10.1038/ng.3192
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The landscape of long noncoding RNAs in the human transcriptome

Abstract: Long non-coding RNAs (lncRNAs) are emerging as important regulators of tissue physiology and disease processes including cancer. In order to delineate genome-wide lncRNA expression, we curated 7,256 RNA-Seq libraries from tumors, normal tissues, and cell lines comprising over 43 terabases of sequence from 25 independent studies. We applied ab initio assembly methodology to this dataset, yielding a consensus human transcriptome of 91,013 expressed genes. Over 68% (58,648) of genes were classified as lncRNAs, of… Show more

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Cited by 2,432 publications
(2,230 citation statements)
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“…Thousands of long noncoding RNAs (lncRNAs; >200 nt) have been identified by genome-wide transcriptome analyses (Lee 2012;Iyer et al 2015). In comparison to mRNA, lncRNAs are characterized by poorer conservation, lower expression levels, and more variable expression between tissues (Guttman et al 2009;Ponting et al 2009;Ulitsky and Bartel 2013).…”
Section: [Supplemental Materials Is Available For This Article]mentioning
confidence: 99%
“…Thousands of long noncoding RNAs (lncRNAs; >200 nt) have been identified by genome-wide transcriptome analyses (Lee 2012;Iyer et al 2015). In comparison to mRNA, lncRNAs are characterized by poorer conservation, lower expression levels, and more variable expression between tissues (Guttman et al 2009;Ponting et al 2009;Ulitsky and Bartel 2013).…”
Section: [Supplemental Materials Is Available For This Article]mentioning
confidence: 99%
“…This has also fostered the rapid accumulation of annotated long noncoding RNAs (lncRNAs) (Bussotti et al 2013) and further recognition that the vast majority of genes express alternative isoforms (Katz et al 2015). Current estimates of human lncRNA loci range from 58,648 from a large compendium of RNA-seq data sets (Iyer et al 2015) to 15,900 lncRNA loci (27,670 transcripts) in the more conservative GENCODE catalog (Harrow et al 2012). The FANTOM3 Consortium identified 34,040 mouse cDNAs lacking coding capability (The FANTOM Consortium et al 2005;Maeda et al 2006), with only 6951 lncRNA loci (9962 transcripts) currently annotated in GENCODE (M4).…”
Section: [Supplemental Materials Is Available For This Article]mentioning
confidence: 99%
“…LncRNAs are defined by a length ranged from 200 bp to 100 kbp and their number is in constant increase: 48,680 lncRNAs are at present identified (5)(6)(7). LncRNAs are important regulators coordinating expression of protein-coding genes nearby (cis-regulation) or at distance (trans-regulation).…”
Section: Introductionmentioning
confidence: 99%