The landscape of postsurgical recurrence patterns in diffuse low-grade gliomas

Ferracci, François-Xavier; Michaud, Karine; Duffau, Hugues

doi:10.1016/j.critrevonc.2019.04.009

Cited by 29 publications

(21 citation statements)

References 59 publications

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“…They are diffusely infiltrating World Health Organization (WHO) grade II brain neoplasms, and DA patients have a median survival in the range of 5-7 years (2). Even with a combination of available therapeutic modalities, including surgery, radiotherapy, and chemotherapy, the invasive growth and resistance to therapy exhibited by these tumors result in their recurrence, malignant transformation, and almost invariable progression to high-grade glioma in most patients (3). These challenges underscore the need for novel strategies to improve the outcomes of patients with low-grade glioma (LGG) (4).…”

Section: Introductionmentioning

confidence: 99%

High Dimensional Mass Cytometry Analysis Reveals Characteristics of the Immunosuppressive Microenvironment in Diffuse Astrocytomas

Wang

et al. 2020

Front. Oncol.

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The tumor immune microenvironment (TIME) plays a pivotal role in tumor development, progression, and prognosis. However, the characteristics of the TIME in diffuse astrocytoma (DA) are still unclear. Leveraging mass cytometry with a panel of 33 markers, we analyzed the infiltrating immune cells from 10 DA and 4 oligodendroglioma (OG) tissues and provided a single cell-resolution landscape of the intricate immune microenvironment. Our study profiled the composition of the TIME in DA and confirmed the presence of immune cells, such as glioma-associated microglia/macrophages (GAMs), CD8+ T cells, CD4+ T cells, regulatory T cells (Tregs), and natural killer cells. Increased percentages of PD-1+ CD8+ T cells, TIM-3+ CD4+ T cell subpopulations, Tregs and pro-tumor phenotype GAMs substantially contribute to the local immunosuppressive microenvironment in DA. DAs and OGs share similar compositions in terms of immune cells, while GAMs in DA exhibit more inhibitory characteristics than those in OG.

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Section: Introductionmentioning

confidence: 99%

High Dimensional Mass Cytometry Analysis Reveals Characteristics of the Immunosuppressive Microenvironment in Diffuse Astrocytomas

Wang

et al. 2020

Front. Oncol.

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“…The treatment of LGG is a comprehensive treatment based on maximum surgical resection, but progression of deterioration is still inevitable, and patients often have adverse outcomes such as multicentre recurrence and meningeal dissemination 10‐12 . SUMOylation, as a covalent modification, occurs mainly in lysine residues 13 and plays an important role in maintaining protein stability and stress response 14 .…”

Section: Discussionmentioning

confidence: 99%

Construction of a SUMOylation regulator‐based prognostic model in low‐grade glioma

Meng

2021

J Cellular Molecular Medi

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Low‐grade glioma (LGG) is an intracranial malignant tumour that mainly originates from astrocytes and oligodendrocytes. SUMOylation is one of the post‐translational modifications but studies of SUMOylation in LGG is quite limited. Transcriptome data, single nucleotide variant (SNV) data and clinical data of LGG were derived from public databases. The differences between the expression of SUMOylation regulators in LGG and normal brain tissue were analysed. Cox regression was used to construct a prognostic model in the training cohort. Kaplan‐Meier survival curves and ROC curves were plotted in the training and the validation cohort to evaluate the effectiveness of the prognostic model. GO and KEGG analyses were applied to preliminarily analyse the biological functions. Compared with normal brain tissue, SENP1 and SENP7 were up‐regulated and SENP5 was down‐regulated in LGG. SUMOylation regulators may be involved in functions such as mRNA splicing, DNA replication, ATPase activity and spliceosome. One prognostic model was established based on the 4 SUMOylation regulator‐related signatures (RFWD3, MPHOSPH9, WRN and NUP155), which had a good predictive ability for overall survival. This study is expected to provide targets for the diagnosis and treatment of low‐grade glioma.

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“…This finding was repeated by two other small studies including 16 and 20 patients with "treatment failures" [22,24]. A recent review on the topic of progression in LGG pointed out that there are few studies, but following more aggressive therapy there is an impression that atypical and non-local progressions and recurrences more often are seen [19].…”

Section: Introductionmentioning

confidence: 86%

“…In our cohort that was not a typical low-risk profile and being based partly upon historical data where biopsies where frequently performed [25], we observed a higher proportion of local progressions and transformations. In low-risk patients undergoing extensive resection the pattern of transformation may be somewhat different, as observed by others that more aggressive therapy leave room for more atypical and distant progression and transformation patterns in the longer-term [19]. We included only patients with radiological transformations, excluding patients with transformation based upon histopathology alone from reoperation without preceding change in MR phenotype.…”

Section: Spatial Distributionmentioning

confidence: 99%

“…Compared to studies on recurrence in high-grade gliomas, [11][12][13][14][15][16][17][18] there are relatively few studies concerning patterns of transformation in LGG [19]. The in vivo growth in highgrade gliomas as depicted by MRI tends to follow white matter tracts and spread is less likely to be perpendicular to white matter tracts [20].…”

Section: Introductionmentioning

confidence: 99%

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Spatial distribution of malignant transformation in patients with low-grade glioma

et al. 2020

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Background Malignant transformation represents the natural evolution of diffuse low-grade gliomas (LGG). This is a catastrophic event, causing neurocognitive symptoms, intensified treatment and premature death. However, little is known concerning the spatial distribution of malignant transformation in patients with LGG. Materials and methods Patients histopathological diagnosed with LGG and subsequent radiological malignant transformation were identified from two different institutions. We evaluated the spatial distribution of malignant transformation with (1) visual inspection and (2) segmentations of longitudinal tumor volumes. In (1) a radiological transformation site < 2 cm from the tumor on preceding MRI was defined local transformation. In (2) overlap with pretreatment volume after importation into a common space was defined as local transformation. With a centroid model we explored if there were particular patterns of transformations within relevant subgroups. Results We included 43 patients in the clinical evaluation, and 36 patients had MRIs scans available for longitudinal segmentations. Prior to malignant transformation, residual radiological tumor volumes were > 10 ml in 93% of patients. The transformation site was considered local in 91% of patients by clinical assessment. Patients treated with radiotherapy prior to transformation had somewhat lower rate of local transformations (83%). Based upon the segmentations, the transformation was local in 92%. We did not observe any particular pattern of transformations in examined molecular subgroups. Conclusion Malignant transformation occurs locally and within the T2w hyperintensities in most patients. Although LGG is an infiltrating disease, this data conceptually strengthens the role of loco-regional treatments in patients with LGG.

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The landscape of postsurgical recurrence patterns in diffuse low-grade gliomas

Cited by 29 publications

References 59 publications

High Dimensional Mass Cytometry Analysis Reveals Characteristics of the Immunosuppressive Microenvironment in Diffuse Astrocytomas

High Dimensional Mass Cytometry Analysis Reveals Characteristics of the Immunosuppressive Microenvironment in Diffuse Astrocytomas

Construction of a SUMOylation regulator‐based prognostic model in low‐grade glioma

Spatial distribution of malignant transformation in patients with low-grade glioma

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