The langerhans cell in human gingival epithelium

Waterhouse, J. P.; Squier, Christopher A.

doi:10.1016/0003-9969(67)90217-8

Cited by 65 publications

(22 citation statements)

References 12 publications

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“…1966;Waterhouse and Squier, 1967). They were highly dendritic in nature and were located primarily on the periphery of the tissue in a manner similar to that of the Langerhans cell.…”

Section: Discussionmentioning

confidence: 96%

Immunocompetent Cells in the Normal Dental Pulp

1987

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The existence and location of various immunocompetent cells in the human dental pulp were investigated. Pulp tissue for analysis was obtained both from clinically intact pre-molars and from third molars without restorations or caries. Frozen and acetone-fixed pulp tissue sections were subjected to indirect immunohistochemistry with monoclonal antibodies to the following cell types: all peripheral T cells, helper/inducer T cells, cytotoxic/suppressor T cells, macrophages, B cells, and Class II antigen-expressing cells. Dendritic cells expressing Class II antigens (HLA-DR, -DQ), indicating a capacity for presentation of antigen to T helper cells, were seen in the odontoblastic layer as well as in the central portions of the pulp tissue. T lymphocytes, divided into helper/inducer and cytotoxic/suppressor cells, were observed in all pulp specimens. B cells were not seen in any of the pulp samples examined. The data demonstrate that the human dental pulp is equipped with immunocompetent cells essential for the initiation of immunological responses.

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“…1966;Waterhouse and Squier, 1967). They were highly dendritic in nature and were located primarily on the periphery of the tissue in a manner similar to that of the Langerhans cell.…”

Section: Discussionmentioning

confidence: 96%

Immunocompetent Cells in the Normal Dental Pulp

1987

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“…A detailed ultrastructural analysis of oral mucosal LCs within gingival epithelium has been studied.-[13] LCs in situ possess between 5 and 9 dendrites that extend out in the same horizontal plane and cover about 25% of the surface area of the skin and mucosa [Figure 1]. [14] Desmosomes and tonofilaments are absent, the nuclei have clefts, and lysosomes, centrioles, Golgi vesicles, small amount of endoplasmic reticulum, and moderate numbers of mitochondria are seen.…”

Section: Introductionmentioning

confidence: 99%

Langerhans cells and their role in oral mucosal diseases

Upadhyay

Agrawal

et al. 2013

North Am J Med Sci

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Dendritic cells are arguably the most potent antigen-presenting cells and may be the only cells capable of initiating the adaptive immune response. The epithelial residents of dendritic cells are Langerhans cells, which serve as the “sentinels” of the mucosa, altering the immune system not only to pathogen entry but also of tolerance to self antigen and commensal microbes. Oral mucosal Langerhans cells are capable of engaging and internalizing a wide variety of pathogens and have been found responsive to nickel in patients with nickel allergies, oral Candida species, oral lichen planus, lichenoid drug eruptions, graft versus host diseases, periodontal diseases median rhomboid glossitis, human immunodeficiency virus infection, hairy leukoplakia of the tongue, and oral squamous cell carcinoma. Review focuses on the role of antigen-presenting cells in particular Langerhans cells to better understand the mechanisms underlying immune responses. In this review, comprehensive detail about mucosal diseases has been compiled using the PubMed database and through textbooks.

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“…Wolff (1972) has pointed out that Langerhans cells are found in stratified squamous epithelia, other than skin epithelia, that have the capacity to keratinize. They have been demonstrated in gingival epithelium (Waterhouse and Squire, 1967); vaginal epithelium (Younes et al. 1968);tonsil (Mâusle et al, 1971); sheep rumen (Gemmell, 1973), and oesophagus (Al Yassin and Toner, 1976).…”

Section: Introductionmentioning

confidence: 99%

Epithelial Kinetics Affect Langerhans’ Cells of Mouse Vaginal Epithelium

Young¹

1985

Cells Tissues Organs

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Langerhans’ cells were found to vary in their morphology and density in the vaginal epithelium of ovariectomized mice stimulated by single daily injections of oestrogen. In ATPase-stained epithelial sheet preparations, Langerhans’ cells were small and stellate in dense distribution after ovariectomy produced epithelial atrophy. They became highly dendritic in sparse distribution as epithelial thickness increased with high mitotic activity. Keratinization when prolonged by daily oestrogen injections did not affect their morphology or distribution.

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The langerhans cell in human gingival epithelium

Cited by 65 publications

References 12 publications

Immunocompetent Cells in the Normal Dental Pulp

Immunocompetent Cells in the Normal Dental Pulp

Langerhans cells and their role in oral mucosal diseases

Epithelial Kinetics Affect Langerhans’ Cells of Mouse Vaginal Epithelium

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