The last word in trial quality? The impact of selection and performance bias within a series of integrated systematic reviews

The results of randomised and non-randomised studies sometimes differed. In some instances non-randomised studies yielded larger estimates of effect and in other instances randomised trials yielded larger estimates of effect. The results of controlled trials with adequate and inadequate/unclear concealment of allocation sometimes differed. When differences occurred, most often trials with inadequate or unclear allocation concealment yielded larger estimates of effects relative to controlled trials with adequate allocation concealment. However, it is not generally possible to predict the magnitude, or even the direction, of possible selection biases and consequent distortions of treatment effects from studies with non-random allocation or controlled trials with inadequate or unclear allocation concealment.

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Randomisation to protect against selection bias in healthcare trials

Odgaard‐Jensen

Vist

Timmer

et al. 2011

Cochrane Database of Systematic Reviews

234

135

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The last word in trial quality? The impact of selection and performance bias within a series of integrated systematic reviews

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Randomisation to protect against selection bias in healthcare trials

Randomisation to protect against selection bias in healthcare trials

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