The latest achievements in thienothiophene chemistry

Diethyl 3,4-dimethylthieno[2,3-b]thiophene-2,5-dicarboxylate

“…For the use of thienthiophenes as versatile precursors for the synthesis of various heterocycles, see: Mabkhot et al (2010Mabkhot et al ( , 2012; Litvinov (2005). For their industrial applications, see: Lee & Sotzing (2001); Heeney et al (2005); Gather et al (2008); He et al (2009).…”

“…They have been developed and tested as potential antitumor, antiviral, antiglaucoma drugs, antiproliferation agents, or as inhibitors of platelet aggregation (Jarak et al, 2006;Egbertson et al, 1999). In addition, thienothiophenes have been used as versatile precursors for synthesis of various heterocycles (Mabkhot et al, 2012, Mabkhot et al, 2010Litvinov, 2005). In view of such important applications, we herein report the crystal structure determination of the title compound (I) to investigate the relationship between its structure and antibacterial activity.…”

Facile one‐pot, three‐component synthesis of novel bis(heterocycles) incorporating thieno[2,3‐b]thiophenes via Michael addition reaction

“…Thienothiophenes have drawn considerable attention from medical point of view as they exhibit a wide spectrum of biological properties including, antibacterial, antiviral, antitumor, and antiglaucoma activities. Many thienothiophene derivatives have also used as inhibitors of platelet aggregation . In addition, push‐pull chromophores derived from thieno[3,2‐ b ]thiophene have potential applications in optical and electronic systems .…”

The Conversion of 5,5′-Bi(1,2,3-dithiazolylidenes) into Isothiazolo[5,4-d]isothiazoles

“…Thienothiophenes are rigid π rich arenes used to build biologically active compounds [1] and semi-conducting or fluorescent small molecules, oligomers and polymers [2,3]. Owing to their high HOMO energy levels, thienothiophenes are oxidatively unstable but this can be overcome by introducing electron withdrawing substituents, or by replacing a ring sp 2 carbon with a more electronegative sp 2 nitrogen.…”