The laxative action of anthracene derivatives

Lemmens, Lien; Dreessen, M

doi:10.1007/bf02293374

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…There is little quantitative data in the literature concerning absorption and excretion of sennosides and its metabolite rhein. [6][7][8][9][10] In general, it is difficult to estimate the absorption and excretion of an herbal medicines because of the presence of various components. To examine the pre-clinical pharmacokinetics of Onpi-to, three compounds were selected as markers based on their levels in this medicine as well as in view of efficacy and safety.…”

mentioning

confidence: 99%

Pharmacokinetics of Rhein from Onpi-to, an Oriental Herbal Medicine, in Rats

Takizawa

Morota

Takeda

et al. 2003

Biological & Pharmaceutical Bulletin

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Onpi-to, an herbal medicine composed of five crude drugs (Rhei Rhizoma, Glycyrrhizae Radix, Ginseng Radix, Zingiberis Rhizoma and Aconiti Tuber), was administered orally to rats. Onpi-to includes 1.240% of total potential rhein derived from sennoside A, sennoside B, rhein 8-O-glucopyranoside and rhein. Plasma, urinary and biliary levels of rhein were determined by an HPLC-UV method. The plasma levels displayed curves characterized by maximum peaks at 8.3+/-5.2 min, 8.3+/-5.2 min and 20.0+/-21.9 min following dosages of 125, 250 and 500 mg/kg with mean concentrations of 1302.5+/-926.4, 2973.6+/-684.3 and 3118.8+/-1701.2 ng/ml, respectively, followed by a subsequent decline. Area under the concentration-time curve (AUC)(0-48 h) at doses of 125, 250 and 500 mg/kg were 752.3+/-321.5, 2443.3+/-554.4 and 4443.2+/-2641.3 ng.h/ml, respectively. In female rats, rhein plasma levels showed curves which had a maximum peak at 45.0+/-16.4 min after a dosage of 250 mg/kg with mean concentration of 3058.0+/-1533.7 ng/ml, followed by a subsequent decline. AUC(0-48 h) was 5537.7+/-1876.0 ng.h/ml. The cumulative urinary excretion of rhein and of conjugated rhein was 3.14+/-1.56% and 38.21+/-18.87% of dose, respectively, 48 h after dosing at 500 mg/kg of Onpi-to in male rats. The cumulative biliary excretion of rhein was 1.34+/-0.44% of dose 48 h after dosing at 500 mg/kg of Onpi-to in male rats.

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mentioning

confidence: 99%

Pharmacokinetics of Rhein from Onpi-to, an Oriental Herbal Medicine, in Rats

Takizawa

Morota

Takeda

et al. 2003

Biological & Pharmaceutical Bulletin

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Rheum spp.

Tang¹,

Eisenbrand²

1992

Chinese Drugs of Plant Origin

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Excretion and distribution of [14C]rhein and [14C]rhein anthrone in rat

Witte

Lemli

1988

Journal of Pharmacy and Pharmacology

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After single intracaecal administration of [14C]rhein (25 mg kg-1) and [14C]rhein anthrone (20 mg kg-1) to rats, the summated recovery rates of 14C after five days were in urine 37(+/- 8.3)% and 2.8(+/- 0.4)% and in faeces 53(+/- 9.5)% and 95 (+/- 10.1)%, respectively. The clearance of radioactivity from the organs and tissues was almost complete within three days, with the exception of the kidney which exhibited pronounced retention of radioactivity even after five days (less than 61% of 24 h values). Extracts of faeces from animals treated with [14C]rhein of [14C]rhein anthrone, revealed rhein as well as other radioactive substances, which chemically did not react as 1,8-dihydroxyanthraquinones.

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The laxative action of anthracene derivatives

Cited by 3 publications

References 6 publications

Pharmacokinetics of Rhein from Onpi-to, an Oriental Herbal Medicine, in Rats

Pharmacokinetics of Rhein from Onpi-to, an Oriental Herbal Medicine, in Rats

Rheum spp.

Excretion and distribution of [14C]rhein and [14C]rhein anthrone in rat

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