The LD50 associated with exposure to the atomic bombing of Hiroshima.

Abstract

Data on a total of 7,593 persons in Hiroshima who were in 2,518 wooden Japanese houses and exposed to A-bomb within 1.6 km from the hypocenter have been used to estimate the LD50/60. The effect of radiation shielding for these people in particularly well-characterized in the new dosimetry system DS86. A range of values emerge, varying slightly with the method of estimation used. This range, derived from DS86 marrow doses, and based on a linear fit to equally weighted estimates of the probabilities of death at various doses, is 2.3-2.6 Gy. A linear estimate in which the probabilities of death at the various doses are weighted by the inverse of their variances is somewhat lower, 2.2 Gy. These values may be underestimates of actual LD50/60 because of inclusion of deaths in the first day, and the severely injured (burns, trauma) who survived the first day but succumbed later to their injuries.

Potential of dark‐striped field mice, Apodemus agrarius coreae, for use as a biological radiation dosimeter for human environments

“…The result suggests that genetic condition is one of the major factors influencing radiation sensitivity in mice. Moreover, this value is similar to 3 to 5 Gy, the LD50/60 value of humans, as reported by Fujita et al (1981). Based on the report of Kim et al (1997), which compared the radiation sensitivity of mice and humans, and the report of Abramsson‐Zetterberg et al (1997), proposing that the radiation sensitivity of A. flavicollis and A. sylvaticus is is similar to that of CBA mice, the possibility of using A. a. coreae as an environmental surveillance dosimeter can be assumed.…”

Potential of Dark-Striped Field Mice, Apodemus agrarius coreae, for Use as a Biological Radiation Dosimeter for Human Environments

“…The result suggests that genetic condition is one of the major factors influencing radiation sensitivity in mice. Moreover, this value is similar to 3 to 5 Gy, the LD50/60 value of humans, as reported by Fujita et al (1981). Based on the report of Kim et al (1997), which compared the radiation sensitivity of mice and humans, and the report of Abramsson-Zetterberg et al (1997), proposing that the radiation sensitivity of A. flavicollis and A. sylvaticusis is similar to that of CBA mice, the possibility of using A. a. coreae as an environmental surveillance dosimeter can be assumed.…”

The LD50 Associated with Exposure to the Atomic Bombing of Hiroshima and Nagasaki

“…Fujita et al 15,16) indicate that exclusion of three strikingly discrepant groups would place the distance LD50 at about 1,100 m.…”

“…This value was arrived at using the preliminary estimates of the FIA kerma values with a reduction for shielding by houses based on the average transmission factors available in 1983. The DS86 marrow dose of an individual in a wooden structure at 892 m was computed by Fujita et al 11,16) to be 2.44 Gy.…”

“…If they were exposed within a building, a scale model was drawn to aid in determining their position, and they were asked to specify how many other individuals to their knowledge were present within the structure, their locations and whether they survived or died, and if the latter, when death occurred, if known18 . Fujita et al 11,16) extracted from these records, data on mortality of 2,518 clusters (a total of 7,593 persons, of whom 1,095 died within 60 days after the bomb) exposed in wooden Japanese houses in Hiroshima. The records also provide data on the estimation of DS86 marrow dose to each cluster (or each individual).…”