Since the 21st century, the experimental teaching in training students' scientific literacy and comprehensive quality plays a major role, more and more studies begin to learn to the experimental teaching mode, however actually the study effect is not ideal, especially under the environment of information technology chemical experiment teaching is particularly scarce. This paper, by using investigation method and interview method to find out the current situation of chemistry teaching under the environment of information technology, and design the 3D interactive simulation of chemical teaching resources, what enable learners to do the experimental activities with subject consciousness and independent consciousness, stimulating learners' learning motivation and effectiveness.