The LDL/HDL ratio predicts long-term risk of coronary revascularization in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: a cohort study

Abstract

Clinical indicators do not adequately predict the long-term prognosis of patients with ST-segment elevation myocardial infarction (STEMI) following percutaneous coronary intervention (PCI). The low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio is expected to be a reliable predictor of the long-term prognosis of these patients. This study aimed to explore the correlation between the LDL/HDL ratio and long-term prognosis in STEMI patients undergoing PCI. Patients with confirmed STEMI who underwent PCI in 7 hospitals in China from January 2009 to December 2011 were enrolled. Information about clinical endpoints, including all-cause death and major adverse cardiovascular events, was collected. Overall, 915 patients were included for analysis, the average follow-up time was 112.2 months. According to the LDL/HDL ratio, the patients were divided into 3 groups using the three-quantile method: low (LDL/HDLp1.963), medium (1.963oLDL/HDLo2.595), and high (LDL/ HDLX2.595) LDL/HDL groups. The rate of coronary revascularization was higher in the high LDL/HDL group (28.52%) than in the low (17.38%, P=0.001) and medium (19.34%, P=0.010) LDL/HDL groups. The hazard ratio of coronary revascularization was significantly higher in the high LDL/HDL group than in the low (P=0.007) and medium (P=0.004) LDL/HDL groups. Increased LDL/HDL ratio was an independent risk factor for long-term coronary revascularization in STEMI patients undergoing PCI (HR=1.231, 95%CI: 1.023-1.482, P=0.028). These findings suggest that an increased LDL/HDL ratio was an independent risk factor for long-term coronary revascularization in STEMI patients undergoing PCI. The risk of coronary revascularization was significantly increased in patients with LDL/HDLX2.595.

Negative-High Titer of Helicobacter pylori Antibody and Lipid Profiles

“…An elevated LDL-C to HDL-C ratio has been known as an important risk factor for coronary heart diseases [ 12 , 13 ]. The present study showed that increasing HP antibody titer was associated significantly higher ratio of LDL-C to HDL-C, which, to the best of our knowledge, has not been investigated in the literature.…”

The Relationship between Severity of Periodontitis and Atherosclerotic Cardiovascular Status in Patients with Acute Myocardial Infarctions: A Prospective Observational Study

“…An increased LDL/HDL ratio was independently associated with long-term coronary revascularization in AMI patients. (22) The importance of lipid management in AMI patients has been mentioned in the guidelines of the European Society of Cardiology and the European Atherosclerosis Society, which recommend that strict management of LDL cholesterol with statins, ezetimibe, and proprotein convertase subtilisin/kexin type 9 inhibitors could reduce the cardiovascular risk. (23) Treatment of PD has been suggested to lower the LDL cholesterol and in ammatory markers, suggesting that an assessment of the PD and implementation of appropriate periodontal interventions in AMI patients might lead to a more effective lipid management.…”

Risk Factors Leading to ST Elevation Myocardial Infarction in Young Patients Presenting to a Tertiary Care Hospital, Islamabad Pakistan

“…STEMI also found to be associated with obesity and male gender and younger individuals al these results are in accordance with results of this study. 14,15 Risk factors are studied in this study on younger individuals of single tertiary care center in Islamabad, for better generalizability study can be conducted in multiple study settings across the country or regions and on a larger sample size. Study concluded that more male young adults were found to be having a STEMI, this could be because more male ratio of patients.…”