2008
DOI: 10.1038/nrmicro1967
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The Legionella pneumophila replication vacuole: making a cosy niche inside host cells

Abstract: The pathogenesis of Legionella pneumophila results from growth of the bacterium within lung macrophages after aerosols are inhaled from contaminated water sources. Interest in this microorganism stems from its ability to manipulate host cell vesicular trafficking pathways and to establish a membrane-bound replication vacuole, making it a model for intravacuolar pathogens. Establishment of the replication compartment requires a specialized translocation system that transports a large cadre of protein substrates… Show more

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Cited by 629 publications
(666 citation statements)
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References 126 publications
(204 reference statements)
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“…typhimurium, the causative agent of a severe human pneumonia, L. pneumophila also establishes a special vacuole named the Legionella-containing vacuole (LCV) after intruding into host cells. 122 L. pneumophila secrets various E3 ligase-mimic effectors via the Dot/Icm T4SS to maintain its intracellular survival. 123 T4SS, despite sharing structural similarity with T3SS, is extensively distributed in both Gramnegative and -positive bacteria and uniquely manages the translocation of not only effector proteins but also toxins and plasmids into host cells.…”
Section: Shigella Flexnerimentioning
confidence: 99%
“…typhimurium, the causative agent of a severe human pneumonia, L. pneumophila also establishes a special vacuole named the Legionella-containing vacuole (LCV) after intruding into host cells. 122 L. pneumophila secrets various E3 ligase-mimic effectors via the Dot/Icm T4SS to maintain its intracellular survival. 123 T4SS, despite sharing structural similarity with T3SS, is extensively distributed in both Gramnegative and -positive bacteria and uniquely manages the translocation of not only effector proteins but also toxins and plasmids into host cells.…”
Section: Shigella Flexnerimentioning
confidence: 99%
“…In macrophages, L. pneumophila is located within vacuoles, the biogenesis of which resembles autophagy [24,25]. Because SQSTM1 interacts with LC3/Atg8, an essential factor for autophagosome formation [26], we assessed the role of SQSTM1 in autophagy of infected macrophages.…”
Section: Acute Pulmonary Inflammation Is Enhanced In Sqstm1 −/− Micementioning
confidence: 99%
“…3F). These results suggest that SQSTM1 is a negative regulator of acute pulmonary inflammation, possibly by regulating inflammasome activity.In macrophages, L. pneumophila is located within vacuoles, the biogenesis of which resembles autophagy [24,25]. Because SQSTM1 interacts with LC3/Atg8, an essential factor for autophagosome formation [26], we assessed the role of SQSTM1 in autophagy of infected macrophages.…”
mentioning
confidence: 99%
“…Within both evolutionarily distant host cells, L. pneumophila evades endocytic fusion and intercepts ER to Golgi vesicle traffic to remodel its phagosome into an ER-derived vacuole (Kagan and Roy, 2002;Molmeret et al, 2005;Shin and Roy, 2008;Isberg et al, 2009). The Dot/Icm type IV secretion system (Segal et al, 1998;Vogel et al, 1998) injects into the host cell a cadre of 200 effectors to modulate a myriad of cellular processes to reprogram the host cell into a proliferation niche (de Felipe et al, 2008;Shin and Roy, 2008;Isberg et al, 2009). The Ankyrin B (AnkB) effector is injected into the host cell by the Dot/Icm system upon bacterial attachment to the plasma membrane and exploits an evolutionarily conserved eukaryotic machinery within mammalian and protozoan cells (Price et al, 2009).…”
mentioning
confidence: 99%
“…The Legionnaires' disease-causing bacterium, Legionella pneumophila, replicates within alveolar macrophages, causing pneumonia (Isberg et al, 2009). The organism is transmitted to humans from the aquatic environment where L. pneumophila replicates within amoeba and ciliates (Molmeret et al, 2005;Franco et al, 2009).…”
mentioning
confidence: 99%