The leukoaraiosis is more prevalent in the large artery atherosclerosis stroke subtype among Korean patients with ischemic stroke

Abstract

Background: Several studies have suggested that the specific stroke subtype may influence the presence of leukoaraiosis in patients with ischemic stroke. We investigated the association between stroke subtype and leukoaraiosis in Korean patients with ischemic stroke by MRI.

White Matter Changes in Cerebrovascular Disease: Leukoaraiosis

“…In the sub analysis of the large-artery-disease group, the leukoaraiosis had a tendency to be more prevalent in the mixed and intracranial stenosis group than did the extracranial stenosis group (45.5% in the mixed group, 40.3% in the intracranial group and 26.9% in the extracranial group, P = 0.08 by chi-square test). The association of leukoaraiosis with largeartery disease in this study might be due to the relatively high prevalence of intracranial occlusive lesions in Korean stroke patients compared to other ethnic groups (Lee et al, 2008). showing an old right temporal lobe ischemic stroke (black arrow), acute left temporo-frontal ischemic stroke (white horizontal arrow), leukoaraiosis (white vertical arrow) and diffusion -hypersignal spots in left temporal lobe (curved white arrows).…”

“…If LA shares with stroke (ischemic and hemorrhagic) common mechanisms, and the appearance of LA on imaging predicts stroke, then, according to the current terminology, LA can be regarded as an intermediate surrogate of stroke. (Jimenez-Conde et al, 2010, Pu et al, 2009, Lee et al, 2008, Inzitari, 2003, as cited by Mijajlovic et al, 2011) Putaala et al hypothesized that risk factors, neuroimaging characteristics, and associations with the overt clinical stroke may be diff erent in young patients with ischemic stroke with or without silent brain infarcts (SBIs) and LA. Of the 669 patients included, 86 (13%) had SBIs, 50 (7%) had LA, 17 (3%) had both, and 550 served as controls.…”

Relationship between Leukoaraiosis and Atherosclerosis Plaques

“…The severity of LA has been associated with the existence of carotid plaque; hence, chronic atherosclerotic diseases have been found to be related to the pathophysiology of leukoaraiosis and its progression 15) . In Korea, a study showed the significant association between leukoaraiosis and the stroke subtypes 16) , although this area has not been investigated in China. The mechanisms, including the impacted parts and the formation of blood vessels between these types, needs further study.…”

The clinical manifestations and pathophysiology of cerebral small vessel disease

“…Hypertension is the most important risk factor for SVD [49] . In patients with a family history of hypertension, the vasculature has already been damaged be- and SBP or DBP [50] .…”