The level of allergens in dust samples collected from selected schools in Shiraz, Iran and its asthma-risk implications

Moghtaderi, Mozhgan; Ashraf, M.; Teshnizi, Saeed Hosseini; Nabavizadeh, Hesamodin; Farjadian, Shirin; Fereidouni, Mohammad

doi:10.1016/j.aller.2019.05.005

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…Our data suggest that ubiquitous environmental factors, such as mites or fungi can lead to airway inflammation and airway hyperreactivity independent of an allergic or IgE-mediated pathway. This may explain why exposure to these components can enhance the development of asthmatic symptoms without the requirement of specific sensitization [9,22].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Chitinase-Induced Airway Hyperreactivity and Inflammation in a Mouse Model of Nonallergic Asthma

Weber‐Chrysochoou

Darcan-Nicolaisen

Wohlgensinger

et al. 2021

Int Arch Allergy Immunol

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Introduction: Environmental exposure to mites and fungi has been proposed to critically contribute to the development of IgE-mediated asthma. A common denominator of such organisms is chitin. Human chitinases have been reported to be upregulated by interleukin-13 secreted in the context of Th2-type immune responses and to induce asthma. We assessed whether chitin-containing components induced chitinases in an innate immune-dependent way and whether this results in bronchial hyperresponsiveness. Materials and Methods: Monocyte/macrophage cell lines were stimulated with chitin-containing or bacterial components in vitro. Chitinase activity in the supernatant and the expression of the chitotriosidase gene were measured by enzyme assay and quantitative PCR, respectively. Non-sensitized mice were stimulated with chitin-containing components intranasally, and a chitinase inhibitor was administered intraperitoneally. As markers for inflammation leukocytes were counted in the bronchoalveolar lavage (BAL) fluid, and airway hyperresponsiveness was assessed via methacholine challenge. Results: We found both whole chitin-containing dust mites as well as the fungal cell wall component zymosan A but not endotoxin-induced chitinase activity and chitotriosidase gene expression in vitro. The intranasal application of zymosan A into mice led to the induction of chitinase activity in the BAL fluid and to bronchial hyperresponsiveness, which could be reduced by applying the chitinase inhibitor allosamidin. Discussion: We propose that environmental exposure to mites and fungi leads to the induction of chitinase, which in turn favors the development of bronchial hyperreactivity in an IgE-independent manner.

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Section: Discussion/conclusionmentioning

confidence: 99%

Chitinase-Induced Airway Hyperreactivity and Inflammation in a Mouse Model of Nonallergic Asthma

Weber‐Chrysochoou

Darcan-Nicolaisen

Wohlgensinger

et al. 2021

Int Arch Allergy Immunol

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“…Sensitivity to cockroaches has been reported to be high (25.8%) among patients with atopic dermatitis in Eastern Iran [11]. Another recent study in Shiraz indicated considerable levels of cockroach allergens in dust samples collected from selected schools [19].…”

Section: Cockroachesmentioning

confidence: 99%

Review of Sensitization to prevalent allergens in Iran and their geographical distribution

Teifoori¹,

Postigo²,

Abtahi³

et al. 2020

vacres

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The prevalence of allergic diseases has been on the rise during past decades. Epidemiological studies have shown that extensive exposure to bio-aerosols causes adverse health effects such as respiratory disorders, allergic reactions and infections. Aeroallergens are allergic airborne particles that disperse from environmental sources over great distances by air currents and ultimately are inhaled by, ingested by, or come into contact with individuals who have had no previous contact with the allergenic agent. The most important bioaerosols in Iran are pollen grains, molds, house dust mites, and animal dander causing many allergic reactions in the country every year. Geographical variation is an important role in the prevalence of allergic diseases, most likely due to different environmental factors. Therefore, identifying geographical and seasonal distribution of allergens not only enables us to warn patients to avoid them but also contributes significantly in the diagnosis, prevention and management of the progress of allergic disorders and provides the possibility of performing immunotherapy. The results of this survey about the most common aeroallergens in different geographic areas of Iran may provide proper prevention activities, vaccine production insights and therefore may reduce the treatment costs for allergic patients.

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“…2 Although asthma is generally characterized by wheezing, cough, chest tightness, and shortness of breath, specific differences in relevant risk factors, age of onset, comorbidity, degree of severity, and response to therapy are discovered in most of the patients, indicating that asthma is heterogeneous. [3][4][5][6] The pathogenesis of asthma is mainly associated with inflammation, airway remodeling, hyperresponsiveness, reversible airway obstruction, and epigenetics. 7,8 Importantly, inflammation plays a pivotal role in asthma pathogenesis, among which inflammation of the airways leads to bronchial hyperresponsiveness, remodeling of the airway wall, and mucus production.…”

Section: Introductionmentioning

confidence: 99%

FoxO4 mediates macrophage M2 polarization by promoting LXA4R expression in an ovalbumin-induced allergic asthma model in mice

2023

Allergol Immunopathol

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Background: Asthma imposes a heavy burden due to its high prevalence. Forkhead box O4 (FoxO4) proteins participate in the modulation of cell progression. However, the role and mechanism of FoxO4 in asthma remains uncharted. Methods: An allergic asthma model was constructed by the induction of ovalbumin and interleukin (IL)-4 in mice and monocyte/macrophage-like Raw264.7 cells, respectively. The role and mechanism of FoxO4 in asthma was determined by pathological staining, immunofluores-cence assay, measurement of inflammatory cells in the blood, reverse transcription quantitative polymerase chain reaction (RT-qPCR), Western blot analysis, and flow cytometry. Results: Ovalbumin treatment triggered an obvious inflammatory cell infiltration with a prominent increase in F4/80+ cell numbers. The relative messenger RNA (mRNA) and protein expressions of FoxO4 were increased in both ovalbumin-induced mice and interleukin-4 (IL-4)-induced Raw264.7 cells. Inhibition of FoxO4 via AS1842856 reduced inflammatory cell infiltration, the number of Periodic Acid Schiff+ (PAS+) goblet cells, the numbers of inflammatory cells in the blood, and the airway resistance in ovalbumin-induced mice. Besides, interference of FoxO4 decreased the number of F4/80+CD206+ cells, and the relative protein expressions of CD163 and Arg1 in vivo and in vitro. Mechanically, suppression of FoxO4 diminished the relative mRNA and protein expressions of LXA4R in both ovalbumin-induced mice and IL-4-induced Raw264.7 cells. Overexpression of LXA4R reversed the outcomes caused by repression of FoxO4, including airway resistance, the number of F4/80+ cells, the proportion of CD206+ cells in ovalbumin-induced mice, and the proportion of F4/80+CD206+ cells in IL-4-induced Raw264.7 cells. Conclusion: FoxO4/LXA4R axis mediated macrophage M2 polarization in allergic asthma.

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The level of allergens in dust samples collected from selected schools in Shiraz, Iran and its asthma-risk implications

Cited by 5 publications

References 27 publications

Chitinase-Induced Airway Hyperreactivity and Inflammation in a Mouse Model of Nonallergic Asthma

Chitinase-Induced Airway Hyperreactivity and Inflammation in a Mouse Model of Nonallergic Asthma

Review of Sensitization to prevalent allergens in Iran and their geographical distribution

FoxO4 mediates macrophage M2 polarization by promoting LXA4R expression in an ovalbumin-induced allergic asthma model in mice

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