The level of interleukin-17 in serum is linked to synovial hypervascularisation in rheumatoid arthritis

Fazaa, A.; Abdelghani, Kawther Ben; Abdeladhim, Maha; Laatar, A.; Ahmed, Mélika Ben; Zakraoui, L.

doi:10.1016/j.jbspin.2014.05.008

Cited by 14 publications

(19 citation statements)

References 4 publications

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“…A controversial role is played by IL‐17A in our model. This proinflammatory and proangiogenic cytokine is extremely important in several pathological conditions, including carcinogenesis and arthritis . Our data show that IL‐17A levels are increased when VEGF is blocked systemically, suggesting a possible compensatory response given by this cytokine.…”

Section: Discussionmentioning

confidence: 71%

The role of high-mobility group box protein 1 in collagen antibody-induced arthritis is dependent on vascular endothelial growth factor

Biscetti

Flex

Pecorini

et al. 2016

Clinical and Experimental Immunology

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Summary High‐mobility group box 1 (HMGB1) has been implicated in angiogenesis and rheumatoid arthritis (RA). The aim of this study was to define more clearly the role of HMGB1 in the synovial angiogenesis and pathogenesis of an immune model of arthritis. BALB/c mice were injected with monoclonal anti‐collagen antibody cocktail followed by lipopolysaccharide to induce arthritis. HMGB1 and vascular endothelial growth factor (VEGF) were over‐expressed in the areas of the synovium where more inflammation and neoangiogenesis were present. The selective blockade of HMGB1 or VEGF resulted alternatively in a lower severity of arthritis evaluated by the arthritis index. Furthermore, exogenous HMGB1 administration caused a worsening of arthritis, associated with VEGF up‐regulation and increased synovial angiogenesis. The selective inhibition of VEGF also resulted in no induction of arthritis in mice receiving exogenous HMGB1. Cytokine enzyme‐linked immunosorbent assay (ELISA) analyses performed on peripheral blood and synovial fluid demonstrated a significant reduction of interleukin (IL)−1β, IL‐6 and tumour necrosis factor (TNF)‐α in mice where HMGB1 and VEGF pathways were blocked. Interestingly, the selective blockade of HMGB1 and VEGF resulted in an increase of the peripheral IL‐17A concentration. The development of arthritis mediated by HMGB1 and the synovial angiogenesis can be blocked by inhibiting the VEGF activity. The proinflammatory and proangiogenic cytokine IL‐17A was increased when HMGB1 is inhibited, but the synovial angiogenesis was nevertheless reduced in this model of arthritis. Taken together, these findings shed new light on the role of this nuclear protein in the pathogenesis of arthritis in an RA‐like model.

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Section: Discussionmentioning

confidence: 71%

The role of high-mobility group box protein 1 in collagen antibody-induced arthritis is dependent on vascular endothelial growth factor

Biscetti

Flex

Pecorini

et al. 2016

Clinical and Experimental Immunology

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“…HLA-DR alleles suggest a pathogenic process at the level of antigen presentation by the MHC molecule (17). Further, comparison of CD45 isoforms in synovial T cells with peripheral blood T cells reveals an enrichment of cells expressing CD45 isoform characteristic of memory T cells in RA synovium (18,19). B Cells B cells also play a key role in the pathogenesis of autoimmune diseases.…”

Section: Immunology T Cellsmentioning

confidence: 99%

Rheumatoid Arthritis: A Chronic Inflammatory Disease and Its Pathophysiology

Rathore¹,

Rathore²,

Singh³

2019

EJMR

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Rheumatoid arthritis is a systemic inflammatory disorder which mainly affects the diarthrodial joint. It has societal effect in terms of cost, disability, and lost productivity. However the pathogenesis of disease is not well understood. Efforts are being made to understand the cellular and molecular mechanism for the pathogenesis of RA. It has been reported that proinflammatory cytokines such as TNF-a, IL-1b, and IL-6 are important mediators of the disease perpetuation. Moreover, there are also reports that free radical generation worsens the disease and contribute towards damage to bone and cartilage. Immune cells such as T cells also impart their role in the progress of the disease. Apart from the conventional treatment strategies using NSAIDs, DMARDs and glucocorticoids newer and safer drugs are continuously being searched, as long term usage of these drugs have resulted in the hepatic and gastrointestinal disorders. Alternative medicine is another therapeutic approach for treatment of the disease, which include herbal and folklore medicines. Many plants and plant products are under scientific exploration to develop a novel therapeutic agent. Here we have tried to review traditional medicine for their potential to treat RA.

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“…The association of plasma IL-6, a major inflammatory cytokine, with joint sonographic findings, specially power Doppler, was demonstrated in early RA [7] and established disease [8]. Plasma IL-17 was associated with joint pD and gray scale synovitis in the hands of RA patients [9]. However, the relationship of MSUS findings with circulating suppressive or inflammatory T cell subtypes has not been addressed so far.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound inflammatory parameters and Treg/Th17 cell profiles in established rheumatoid arthritis

et al. 2019

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Background: Imbalance and disfuntion in regulatory T-cells (Tregs) and IL-17 producer lymphocytes (Th17) have been implicated in the pathogenesis of rheumatoid arthritis (RA). Gray scale synovial proliferation (GS), power Doppler signal (pD) and bone erosions seen on high resolution muskuloskeletal ultrasound (MSUS) are hallmarks of destructive articular disease. Objective: To evaluate the association of peripheral Tregs and Th17 with MSUS findings in RA. Methods: RA patients (1987 ACR criteria) treated with disease-modifying antirheumatic drugs (DMARDs) were included. Lymphocytes were isolated and immunophenotyped by flow cytometry to investigate regulatory FoxP3+ T cells and IL-17+ cells. MSUS (MyLab 60, Esaote, Genova, Italy, linear probe 6-18 MHz) was performed on hand joints, and a 10-joint US score was calculated for each patient. Results: Data on lymphocytes subsets were avaiable for 90 patients. The majority of patients were Caucasian women with a median disease duration of 6 years (interquartile range: 2-13 years). Mean DAS28 was 4.28 (SD ± 1.64) and mean HAQ score was 1.11 (SD ± 0.83). There was no significant correlation of 10-joint GS score (rS = 0.122, 95% CI: − 0.124 to 0.336, P = 0.254) and 10-joint pD score (rS = 0.056, 95% CI: − 0.180 to 0.273, P = 0.602) with the mean percentage of peripheral Treg cells. Also, 10-joint GS score (rS = 0.083, 95% CI: − 0.125 to 0.302, P = 0.438) and 10-joint pD score 10 (rS = − 0.060, 95% CI: − 0.271 to 0.150, P = 0.575); did not correlate to Th17 profile. No association of bone erosions on MSUS with Treg and Th17 profiles (P = 0.831 and P = 0.632, respectively) was observed. Conclusion: In this first study addressing MSUS features and lymphocytes subtypes in established RA, data did not support an association of circulating Tregs and Th17 lymphocytes with inflammatory and structural damage findings on MSUS.

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The level of interleukin-17 in serum is linked to synovial hypervascularisation in rheumatoid arthritis

Cited by 14 publications

References 4 publications

The role of high-mobility group box protein 1 in collagen antibody-induced arthritis is dependent on vascular endothelial growth factor

The role of high-mobility group box protein 1 in collagen antibody-induced arthritis is dependent on vascular endothelial growth factor

Rheumatoid Arthritis: A Chronic Inflammatory Disease and Its Pathophysiology

Ultrasound inflammatory parameters and Treg/Th17 cell profiles in established rheumatoid arthritis

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