The level of Krüppel-like factor 8 expression predicts prognosis and metastasis in various carcinomas

Li, Jun; Zheng, Huimin; Ding, Yangyang; Li, Manman; Li, Jingrong; Guo, Jiaojiao; Hu, Linhui; Pu, Lianfang; Xiong, Sheng

doi:10.1097/md.0000000000015519

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…In breast cancer, cancer stem-like cells (CSC) can alter energy metabolism to focus on the hexosamine biosynthesis pathway (HBP) to permit increased cell proliferation [ 100 , 101 ]. High KLF8 expression is associated with poor prognosis of breast cancer patients and was found to play a role in the HBP [ 102 , 103 ]. About 2–5% of glucose and glutamine transported into the cell enter the HBP to generate UDP-GlcNAc.…”

Section: Breast Cancermentioning

confidence: 99%

SP and KLF Transcription Factors in Cancer Metabolism

Orzechowska-Licari

LaComb

Mojumdar

et al. 2022

IJMS

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Tumor development and progression depend on reprogramming of signaling pathways that regulate cell metabolism. Alterations to various metabolic pathways such as glycolysis, oxidative phosphorylation, lipid metabolism, and hexosamine biosynthesis pathway are crucial to sustain increased redox, bioenergetic, and biosynthesis demands of a tumor cell. Transcription factors (oncogenes and tumor suppressors) play crucial roles in modulating these alterations, and their functions are tethered to major metabolic pathways under homeostatic conditions and disease initiation and advancement. Specificity proteins (SPs) and Krüppel-like factors (KLFs) are closely related transcription factors characterized by three highly conserved zinc fingers domains that interact with DNA. Studies have demonstrated that SP and KLF transcription factors are expressed in various tissues and regulate diverse processes such as proliferation, differentiation, apoptosis, inflammation, and tumorigenesis. This review highlights the role of SP and KLF transcription factors in the metabolism of various cancers and their impact on tumorigenesis. A better understanding of the role and underlying mechanisms governing the metabolic changes during tumorigenesis could provide new therapeutic opportunities for cancer treatment.

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Section: Breast Cancermentioning

confidence: 99%

SP and KLF Transcription Factors in Cancer Metabolism

Orzechowska-Licari

LaComb

Mojumdar

et al. 2022

IJMS

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“…35 The level of KLF8 expression predicts prognosis and metastasis in various carcinomas. 36 Few studies have investigated the expression of KLF8 and vimentin in PC. The aim of this study was to assess their expression in CTCs from peripheral blood and their association with patient prognosis.…”

Section: Introductionmentioning

confidence: 99%

Circulating Tumor Cells Expressing Krüppel-Like Factor 8 and Vimentin as Predictors of Poor Prognosis in Pancreatic Cancer Patients

Zhu¹,

Liu²,

Liu³

et al. 2021

Cancer Control

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Background: Circulating tumor cells (CTCs) with an epithelial-mesenchymal transition phenotype in peripheral blood may be a useful marker of carcinomas with poor prognosis. The aim of this study was to determine the prognostic significance of CTCs expressing Krüppel-like factor 8 (KLF8) and vimentin in pancreatic cancer (PC). Methods: CTCs were isolated by immunomagnetic separation from the peripheral blood of 40 PC patients before undergoing surgical resection. Immunocytochemistry was performed to identify KLF8+ and vimentin+ CTCs. The associations between CTCs and time to recurrence (TTR), clinicopathologic factors, and survival were assessed. Univariate and multivariate analyzes were performed to identify risk factors. Results: Patients with CTCs ( n = 30) had a higher relapse rate compared to those without ( n = 10) (70.0% vs 20.0%; P < 0.01). The proportion of KLF8+/vimentin+ CTCs to total CTCs was inversely related to TTR ( r = −0.646; P < 0.01); TTR was reduced in patients with > 50% of CTCs identified as KLF8+/vimentin+ ( P < 0.01). Independent risk factors for recurrence were perineural invasion and > 50% KLF8+/vimentin+ CTCs (both P < 0.05). Conclusion: Poor prognosis can be predicted in PC patients when > 50% of CTCs are positive for KLF8 and vimentin.

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