The level of lipopolysaccharide-binding protein is significantly increased in plasma in patients with the systemic inflammatory response syndrome

Myc, Andrzej; Buck, Jackie; Gonin, J; Reynolds, Brice S; Hämmerling, Ulrich; Emanuel, David

doi:10.1128/cdli.4.2.113-116.1997

Cited by 77 publications

(45 citation statements)

References 28 publications

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“…Differences in the two patient populations could also affect the observed differences in LBP levels. It should be noted that the LBP values for RA subjects reported by Wen et al (90) were comparable with those reported for sepsis and other severe illnesses (73,94,95). Furthermore, their reported CRP values were substantially higher than those for our cohort.…”

Section: Discussionsupporting

confidence: 84%

“…Lysozyme is an important bacteriolytic enzyme produced by monocytes, macrophages, neutrophils, dendritic cells and glandular cells (52,97). The antimicrobial potential of lysozyme is derived from its ability to hydrolyze the glycosidic bond of peptidoglycan, which is found in the cell walls of both Gram-positive and Gram-negative bacteria (94). In circulation, lysozyme facilitates the degradation of bacterial peptidoglycan into peptidoglycan monomers.…”

Section: Discussionmentioning

confidence: 99%

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Heightened Levels of Antimicrobial Response Factors in Patients With Rheumatoid Arthritis

et al. 2020

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Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease leading to considerable disability over time. The disease can be characterized by the presence of multiple autoantibodies in the serum and synovial fluid. Microbial dysbiosis is proposed to play a role in the pathogenesis of RA. Increased systemic bacterial exposure leads to elevated levels of antimicrobial response factors (ARFs) in the circulation. In the present study, we tested whether RA patients have increased levels of ARFs by analyzing the levels of multiple ARFs in serum from RA patients and healthy age and sex-matched controls. The levels of soluble CD14 (sCD14), lysozyme, and CXCL16 were significantly elevated in RA patients compared to healthy controls. Lipopolysaccharide binding protein (LBP) levels remained unchanged in RA patients compared to healthy controls. A positive correlation of LBP with rheumatoid factor (RF) was also found in RA subjects. Interestingly, the levels of anti-endotoxin core antibodies (EndoCAb) IgM, total IgM, EndoCAb IgA, and total IgA were significantly elevated in RA patients compared to healthy controls. No significant changes in the levels of EndoCAb IgG and total IgG were observed in RA patients compared to healthy controls. Furthermore, lysozyme and CXCL16 levels were positively correlated with disease severity among RA subjects. Increases in the levels of several ARFs and their correlations with clinical indices suggest systemic microbial exposure in the RA cohort. Modulation of microbial exposure may play an important role in disease pathogenesis in individuals with RA.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Heightened Levels of Antimicrobial Response Factors in Patients With Rheumatoid Arthritis

et al. 2020

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“…According to previous investigators, LBP is both a bacterial translocation biomarker and an acute phase protein identifying the presence of systemic infection. 20 Studies in humans have shown that LBP concentration increased in the presence of bacterial infection. [20][21][22] In our cohort, LBP was highly correlated with other markers of infection Previous investigators have demonstrated that LBP levels were increasing with severity of cirrhosis and portal hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…20 Studies in humans have shown that LBP concentration increased in the presence of bacterial infection. [20][21][22] In our cohort, LBP was highly correlated with other markers of infection Previous investigators have demonstrated that LBP levels were increasing with severity of cirrhosis and portal hypertension. 23,24 High levels were also determined in cirrhotics with ascites compared to those without.…”

Section: Discussionmentioning

confidence: 99%

High serum lipopolysaccharide binding protein is associated with increased mortality in patients with decompensated cirrhosis

Agiasotelli

Alexopoulou

Vasilieva

et al. 2016

Liver International

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“…In patients with sepsis, LBP levels are high. 7 Consequently, LPS is efficiently solubilized, resulting in high numbers of LPS-LBP complexes and the inflammatory response continues to grow as more of these complexes are presented to responsive immune cells. LPS signal transduction pathways.…”

Section: Lps-mediated Activation Of Peripheral Blood Monocytesmentioning

confidence: 99%

Targeting Bacterial Endotoxin

Bosshart

Heinzelmann

2007

Annals of the New York Academy of Sciences

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The term sepsis describes a potentially lethal clinical condition that develops as a result of a dysregulated host response to bacterial infection. The most common bacterial component implicated in initiating the septic syndrome is a cell wall molecule derived from Gram-negative bacteria, known as lipopolysaccharide (LPS) or endotoxin. Like all mammals, humans are equipped with an LPS-sensing machinery consisting, primarily, of LPS-binding protein (LBP), CD14, a glycosylphosphatidylinositol (GPI)-anchored monocyte differentiation antigen, and toll-like receptor 4 (TLR4), a signal-transducing integral membrane protein. Modest stimulation of TLR4 facilitates the elimination of invading microorganisms. Potent TLR4 stimulation, however, produces severe reactions in the host, often leading to multiple organ failure and death. The search for pharmaceuticals that reduce mortality in septic patients has been a painstaking process. Thus far, only a few compounds have been found to significantly reduce mortality rates. Perhaps one of the more promising therapeutic strategies currently pursued is based on the identification of synthetic or naturally occurring substances that neutralize LPS or inhibit LPS-mediated activation of host immune cells, such as monocytes and macrophages. Here, we describe a number of diverse molecular structures with a capacity to either enhance or blunt LPS-induced monocyte activation. The underlying molecular mechanisms are discussed.

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The level of lipopolysaccharide-binding protein is significantly increased in plasma in patients with the systemic inflammatory response syndrome

Cited by 77 publications

References 28 publications

Heightened Levels of Antimicrobial Response Factors in Patients With Rheumatoid Arthritis

Heightened Levels of Antimicrobial Response Factors in Patients With Rheumatoid Arthritis

High serum lipopolysaccharide binding protein is associated with increased mortality in patients with decompensated cirrhosis

Targeting Bacterial Endotoxin

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