The Level of Nesfatin -1, Calcium and Vitamin D in Women with Gestational Diabetes Versus Control

Abstract

Objective:This study was designed to investigate serum level nesfatin-1 and determine the association of nesfatin-1, calcium level and 25-hydroxy vitamin D (25(OH )D) level in women with gestational diabetes mellitus (GDM) versus controls Methods: A88 pregnant women at 24-28 weeks gestation were included in this study .Forty four women diagnosed with gestational diabetes and 44 women without gestational diabetes both groups were matched in age and body mass index . Then we classify each group depended on 25(OH) D status (sufficient, insufficient and deficient). nesfatin-1 and vitamin D levels were analyzed using ELISA (enzyme link immunosorbent assay) a cut off value for serum calcium were assessed using colorimetric method, cut off value were used according to manufacture instruction and the a comparison was done between above parameters. Furthermore, insufficient and deficient 25(OH)D gestational diabetes group had significantly higher fasting blood sugar compared to matched control group . Conclusion:Nesfatin-1 levels, 25(OH)D and calcium were not differ between the two groups statistically.