2005
DOI: 10.1016/j.drugalcdep.2005.01.002
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The level of response to alcohol in daughters of alcoholics and controls

Abstract: Background: The low level of response (LR) to alcohol is a genetically influenced characteristic related to the development of alcohol use disorders (AUDs). This phenotype is found in men with a family history (FH) of alcoholism, predicts future AUDs, and has heritabilities as high as 60%. However, despite evidence of genetic influences for AUDs in both sexes, the majority of studies evaluating differences in LR across high-and low-risk groups have been conducted on males, and it is unclear how generalizable t… Show more

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Cited by 95 publications
(102 citation statements)
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References 85 publications
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“…To develop 2 groups for comparison, a median split (SHAS median = 4.85) was performed to classify participants as having a low level of response (n = 5; mean 3.51 ± 0.98 SD) versus a high level of response (n = 5; mean 10.57 ± 3.56 SD) to alcohol based on SHAS responses 27 minutes after alcohol administration, just before entering the FMRI scanner (overall mean 7.04 ± 4.46 SD). These values are comparable with previous studies on level of response to similar doses of alcohol using the SHAS, with low-level responders here falling toward the lower end of previously published ranges (e.g., Eng et al, 2005;Schuckit et al, 2000). A repeated-measures multivariate ANOVA, with condition ( placebo or alcohol) and working memory load (2-, 4-, or 6-dot) as within-subjects factors, analyzed the behavioral measures and neural activation patterns in areas that showed a significant condition by working memory load interaction.…”
Section: Data Processing and Analysissupporting
confidence: 81%
“…To develop 2 groups for comparison, a median split (SHAS median = 4.85) was performed to classify participants as having a low level of response (n = 5; mean 3.51 ± 0.98 SD) versus a high level of response (n = 5; mean 10.57 ± 3.56 SD) to alcohol based on SHAS responses 27 minutes after alcohol administration, just before entering the FMRI scanner (overall mean 7.04 ± 4.46 SD). These values are comparable with previous studies on level of response to similar doses of alcohol using the SHAS, with low-level responders here falling toward the lower end of previously published ranges (e.g., Eng et al, 2005;Schuckit et al, 2000). A repeated-measures multivariate ANOVA, with condition ( placebo or alcohol) and working memory load (2-, 4-, or 6-dot) as within-subjects factors, analyzed the behavioral measures and neural activation patterns in areas that showed a significant condition by working memory load interaction.…”
Section: Data Processing and Analysissupporting
confidence: 81%
“…This may refl ect the facts that females weigh less, have less body water, and metabolize alcohol a bit slower than males and, thus, have a higher BAC per drink consumed (Eng et al, 2005). In all models, gender also related to alcohol outcomes either directly or via mediation by PEER.…”
Section: Discussionmentioning
confidence: 93%
“…A low level of response to alcohol is more common in both men and women with a first-degree family history of an AUD (Eng et al, 2005;Schuckit and Smith, 1996). This relationship has been found across ethnic groups, including Caucasians, Hispanics, and Native Americans (Ehlers et al, 1999;Schuckit et al, , 2006.…”
mentioning
confidence: 79%