The level of serum bilirubin associated with coronary lesion types in patients with coronary artery disease

Wei, Shipeng; Gao, C Y; Wei, Guoqian; Chen, Yan-Jun; Zhong, Lintao; Li, Xueqi

doi:10.2459/jcm.0b013e32834a3967

Cited by 18 publications

(17 citation statements)

References 33 publications

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“…The same result was obtained by Taban Sadeghi et al (2015) who evaluated the relation between serum bilirubin levels with coronary diseases based on angiographic findings, a significant difference was observed between verge total bilirubin levels in two groups: patients with normal angiography & with 3 vessels involved, A reverse relation was observed in this study between total bilirubin levels, number of vessels affected, the severity of stenosis and type of coronary vessel [28]. Wei et al (2012) also showed similar results with a significant inverse correlation between CAD and total bilirubin (n = 1260) in patients who underwent coronary angiography [12].…”

Section: Discussionsupporting

confidence: 89%

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Serum Bilirubin as a Predictor of Coronary Artery Disease Severity in Patients Undergoing Primary Percutaneous Coronary Intervention

Khalil¹,

Ibrahim²,

Elmalla³

2019

WJCD

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Introduction: Coronary artery disease (CAD) is one of the most common causes of death worldwide. In 2010, about 7 out of total 53 million deaths were due to ischemic heart disease. The aim of this study is to evaluate the relationship of serum bilirubin level with the severity and complexity of coronary artery disease (CAD) in the patients undergoing primary percutaneous coronary intervention (PCI). Materials and Methods: 70 patients with STEMI who were undergoing primary PCI were included in the study. All the patients included in the study were subjected to full routine investigations and standard coronary angiographic projections. Total bilirubin level was measured and the patients were divided into two groups. Group 1 was with serum TB (<1 mg/dl) and Group 2 was with serum TB (>1 mg/dl). Severity and complexity of coronary artery lesions will be assessed using Gensini score. Results: After PCI, the two studied groups were compared regarding the number of vessels affected by one and more than one vessel disease.

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Section: Discussionsupporting

confidence: 89%

“…According to Wei et al (2012), a significant inverse correlation between CAD and total bilirubin (n = 1260) in patients who underwent coronary angiography [12].…”

Section: ) Identification Of An Intracoronary Thrombus By Angiographmentioning

confidence: 97%

Serum Bilirubin as a Predictor of Coronary Artery Disease Severity in Patients Undergoing Primary Percutaneous Coronary Intervention

Khalil¹,

Ibrahim²,

Elmalla³

2019

WJCD

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“…As it is well known that the proportion of HDL and LDL in the TC would be Data are represented as number (%) or mean±SD. As we reported previously, it is associated with coronary artery lesion types [8]. more valuable, it is well accepted that the ratio of LDL and HDL cholesterol is a powerful predictor for cardiovascular diseases [16,17].…”

Section: Discussionmentioning

confidence: 56%

“…Cystatin C (Cys C), however, is a recently discovered biomarker, having a role in the evaluation of renal function [8][9][10]. Uric acid, homocysteine, and so forth are used as indexes for inflammatory diseases as well.…”

Section: Introductionmentioning

confidence: 99%

Cystatin C associates with the prediction of in-stent restenosis among patients receiving stent implantation

Zhao

Yang

Mao

et al. 2013

Coronary Artery Disease

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“…These findings suggest a possible protective effect of elevated serum bilirubin levels against myocardial ischemia in patients with chronic total coronary occlusion with collaterals limiting infarct size and providing additional blood flow to the ischemic area[29]. Wei et al[30] also showed similar results with a significant inverse correlation between CAD and total bilirubin ( n = 1260) in patients who underwent coronary angiography.…”

Section: Evidence Supporting the Protective Effect Of Bilirubin On Cadmentioning

confidence: 78%

Bilirubin in coronary artery disease: Cytotoxic or protective?

Gupta

Singh

Chaudhary

et al. 2016

WJGPT

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Bilirubin has traditionally been considered a cytotoxic waste product. However, recent studies have shown bilirubin to have anti-oxidant, anti-inflammatory, vasodilatory, anti-apoptotic and anti-proliferative functions. These properties potentially confer bilirubin a new role of protection especially in coronary artery disease (CAD), which is a low grade inflammatory process exacerbated by oxidative stress. In fact, recent literature reports an inverse relationship between serum concentration of bilirubin and the presence of CAD. In this article, we review the current literature exploring the association between levels of bilirubin and risk of CAD. We conclude that current evidence is inconclusive regarding the protective effect of bilirubin on CAD. A causal relationship between low serum bilirubin level and increased risk of CAD is not currently established.

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The level of serum bilirubin associated with coronary lesion types in patients with coronary artery disease

Abstract: Total serum bilirubin level is an independent risk factor for CAD. It has a strong relationship with coronary artery lesion types.

Cited by 18 publications

References 33 publications

Serum Bilirubin as a Predictor of Coronary Artery Disease Severity in Patients Undergoing Primary Percutaneous Coronary Intervention

Serum Bilirubin as a Predictor of Coronary Artery Disease Severity in Patients Undergoing Primary Percutaneous Coronary Intervention

Cystatin C associates with the prediction of in-stent restenosis among patients receiving stent implantation

Bilirubin in coronary artery disease: Cytotoxic or protective?

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