The level of serum visfatin (PBEF) is associated with total number of B cells in patients with rheumatoid arthritis and decreases following B cell depletion therapy

Šenolt, Ladislav; Kryštůfková, Olga; Hulejová, Hana; Kuklová, Markéta; Filková, Mária; Cerezo, Lucie Andrés; Běláček, Jaromír; Haluzı́k, Martin; Forejtová, Šárka; Pavelka, Karel; Vencovský, Jiří

doi:10.1016/j.cyto.2011.04.004

Cited by 31 publications

(37 citation statements)

References 27 publications

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“…PBEF has been found to be associated with several inflammatory diseases, including acute lung injury, clinical sepsis, and rheumatoid arthritis, among others (Jia et al, 2004;Liu et al, 2009;Senolt et al, 2011). However, this is the first study to examine PBEF in childhood HLH.…”

Section: Discussionmentioning

confidence: 81%

“…Thus, whether PBEF is a cytokine remains unclear. However, numerous studies have indicated that PBEF acts as a cytokine and is implicated in several inflammatory diseases, including acute lung injury, clinical sepsis, and rheumatoid arthritis, among others (Jia et al, 2004;Liu et al, 2009;Senolt et al, 2011). PBEF has been found to upregulate a variety of inflammatory cytokines, including tumor necrosis factor (TNF)-a, IL-1β, IL-6, transforming growth factor-b1, IL-16, and C-C chemokine receptor type 3 (Moschen et al, 2007;Song et al, 2008;Liu et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Pre-B-cell colony-enhancing factor is markedly elevated in childhood hemophagocytic lymphohistiocytosis

Gao

Bhandari

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome involving a final common pathway of hypercytokinemia, in which tumor necrosis factor (TNF)-a, interferon (IFN)-g, and soluble interleukin 2-receptor-alpha (sIL-2Ra) are the key cytokines. Pre-B-cell colony-enhancing factor (PBEF) is an inflammatory cytokine involved in several inflammatory diseases. However, its role in HLH is unknown. In this study, we examined the role of PBEF in HLH. Plasma was collected from 22 children with HLH and 14 healthy children. The concentrations of plasma PBEF, TNF-a, IFN-g, and sIL2Ra were determined using an enzyme-linked immunosorbent assay. All clinical data were derived from medical records. In the acute phase, children with HLH had much higher PBEF, TNF-a, IFN-g, and sIL2Ra levels than did healthy children (P < 0.05). After treatment, 13 HLH children improved and PBEF, TNF-a, and IFN-g levels decreased to normal levels (P < 0.05); sIL-2Ra levels also decreased (P < 0.05), but remained above the normal level (P < 0.05). Two patients were lost to follow-up, while 7 patients showed a bad response to therapy and eventually died, showing high PBEF levels above those of the survivors (P < 0.01). PBEF level was significantly positively correlated with TNF-a, IFN-g, sIL-2Ra, serum ferritin, and triglycerides (all P < 0.05), and was negatively correlated with fibrin (P < 0.05). PBEF appears to be involved in the inflammatory process of HLH, and elevated PBEF is related to disease activity. We are currently evaluating the role of PBEF as a marker for the diagnosis and management of patients.

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Pre-B-cell colony-enhancing factor is markedly elevated in childhood hemophagocytic lymphohistiocytosis

Gao

Bhandari

et al. 2015

Genet. Mol. Res.

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“…Likewise, visfatin levels in RA patients have been correlated positively with the total number of B cells [24]. Despite this mounting evidence, other reports have shown opposite results regarding visfatin's correlation with disease activity [24,29].…”

Section: Introductionmentioning

confidence: 94%

“…Visfatin: a new player in rheumatic diseases 11 that baseline serum visfatin levels are positively associated with radiographic progression of RA over 4 years, mainly due to its correlation with anti-CCP antibodies [27] Accordingly, its level was also correlated with Larsen scores [23], inflammation degree, and clinical disease activity [28]. Likewise, visfatin levels in RA patients have been correlated positively with the total number of B cells [24]. Despite this mounting evidence, other reports have shown opposite results regarding visfatin's correlation with disease activity [24,29].…”

Section: Introductionmentioning

confidence: 99%

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Visfatin: a new player in rheumatic diseases

Gómez

Suárez²,

Villalvilla³

et al. 2013

Immunometabolism

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During the last 50 years the number of overweight and obese people in developed countries has increased dramatically. The consequences of this excessive fat accumulation have been associated with a multitude of comorbidities, mainly related to the cardiovascular system and glucose and lipid metabolism. However, obesity also has an impact on other diseases, as an enhancer of certain pathological aspects or as a susceptibility factor, including certain rheumatic diseases such as rheumatoid arthritis (RA), osteoarthritis (OA) and systemic lupus erythematosus (SLE). The link between obesity and these rheumatic diseases has been purported to be via the action of metabolic factors produced by adipose tissue, adipokines. Among these adipokines are leptin and adiponectin, which have been extensively studied. Our knowledge of the role of other relevant newer adipokines, such as visfatin, in the arthritides is rapidly growing. Therefore, in this review our aim is to summarize the current literature regarding the association between visfatin and the most relevant rheumatic diseases.

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Adipokines, Molecular Players at the Crossroad Between Inflammation and Oxidative Stress: Role in Arthropathies

Scotece

Conde

Gómez

et al. 2012

Studies on Arthritis and Joint Disorders

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The level of serum visfatin (PBEF) is associated with total number of B cells in patients with rheumatoid arthritis and decreases following B cell depletion therapy

Cited by 31 publications

References 27 publications

Pre-B-cell colony-enhancing factor is markedly elevated in childhood hemophagocytic lymphohistiocytosis

Pre-B-cell colony-enhancing factor is markedly elevated in childhood hemophagocytic lymphohistiocytosis

Visfatin: a new player in rheumatic diseases

Adipokines, Molecular Players at the Crossroad Between Inflammation and Oxidative Stress: Role in Arthropathies

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