The level of the neudesin in Type-2 Diabetic patients and the relationship between the metabolic parameters and carotid intima-media thickness

Karatas, Ovgu; Çalan, Mehmet; Yüksel, Arif; Chousein, Roukie; Bozkaya, Giray; Karataş, Murat; Uslu, Adam; Tatar, Erhan

doi:10.23736/s0391-1977.20.03217-4

Cited by 8 publications

(10 citation statements)

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“…On the other hand, recently Karatas et al. ( 20 ) reported higher serum levels of neudesin in adult patients with newly diagnosed T2MD compared to controls matched for age and BMI ( 20 ). However, the serum concentrations of neudesin detected by Karatas et al.…”

Section: Discussionmentioning

confidence: 99%

“…In the latter group, no correlation was found between neudesin and glycemia, glycemic control or disease progression ( 22 ). Conversely, serum levels of neudesin showed a direct correlation with HOMA-IR and BMI ( 20 ). In partial agreement with the latter data, we found that plasma levels of neudesin in obese and overweight children are directly correlated with glycemia and glucose AUC after oral loading.…”

Section: Discussionmentioning

confidence: 99%

“…In neudesin gene knockout mice, increased energy expenditure, lipolysis in white adipose tissue, heat production of brown adipose tissue, and a protection to IR related to high-fat diet and decreased food intake were shown (16); these data have thus led to focus attention on the action of neudesin as a possible negative regulator of energy expenditure. However, few and discordant studies are available in the literature on the levels of neudesin in biological fluids of patients (17)(18)(19)(20)(21)(22)(23) and no data on childhood obesity are yet available.…”

Section: Introductionmentioning

confidence: 99%

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Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children

et al. 2022

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Childhood overweight and obesity are among the major health problems of modern times, especially in Western countries, due to their association with increased cardiovascular and cancer risk in adulthood. Neudesin, a recently discovered peptide secreted mainly in the brain and adipose tissue, is being investigated for its possible activity as a negative regulator of energy expenditure. We conducted a cross-sectional observational preliminary study with the aim of testing the hypothesis that plasma levels of neudesin can be modified in obese and overweight children and to evaluate any possible relationship between plasma neudesin levels and metabolic and anthropometric parameters. 34 Children (Tanner’s stage 1) were included and divided in two groups according to Cole’s criteria. Group A included obese and overweight children (23 patients, 17 females and 6 males, aged 4-10 years); Group B included healthy normal-weight children (11 subjects, 7 females and 4 males, aged 3-10 years). Metabolic (glucose and insulin, total, LDL- and HDL-cholesterol, triglycerides, uric acid) and hormonal (fT3, fT4, TSH, IGF-1, leptin) parameters were evaluated. HOMA-IR and QUICKI index and the area under the curve (AUC) of glucose and insulin after oral glucose load were calculated in obese and overweight children. Neudesin was measured by ELISA. Neudesin levels were significantly higher in obese/overweight children than in controls. In obese and overweight children, plasma neudesin levels were significantly directly correlated with blood glucose and glucose AUC. Taken together, these results, although preliminary, may suggest a possible age-related role of neudesin in glucose homeostasis in obese/overweight children.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children

et al. 2022

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“…The other category, T2DM is more prevalent and common in adults. T2DM is caused by a combination of resistance to insulin action (IR) and an inadequate compensatory insulin secretory response ( Henning., 2018 ; Karatas et al, 2021 ). Diabetes is known to contribute to cardiovascular and cerebrovascular diseases ( Yahagi et al, 2017 ), renal failure ( Braunwald., 2019 ), and other complications.…”

Section: The Wnt Signaling Pathway and Diabetesmentioning

confidence: 99%

The Wnt Signaling Pathway in Diabetic Nephropathy

Wang

Zhang

et al. 2022

Front. Cell Dev. Biol.

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Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2 diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease. DN can lead to hypertension, edema, and proteinuria. In some cases, DN can even progress to kidney failure, a life-threatening condition. The precise etiology and pathogenesis of DN remain unknown, although multiple factors are believed to be involved. The main pathological manifestations of DN include mesangial expansion, thickening of the glomerular basement membrane, and podocyte injury. Eventually, these pathological manifestations will lead to glomerulosclerosis, thus affecting renal function. There is an urgent need to develop new strategies for the prevention and treatment of DN. Existing evidence shows that the Wnt signaling cascade plays a key role in regulating the development of DN. Previous studies focused on the role of the Wnt canonical signaling pathway in DN. Subsequently, accumulated evidence on the mechanism of the Wnt non-canonical signaling indicated that Wnt/Ca2+ and Wnt/PCP also have essential roles in the progression of DN. In this review, we summarize the specific mechanisms of Wnt signaling in the occurrence and development of DN in podocyte injury, mesangial cell injury, and renal fibrosis. Also, to elucidate the significance of the Wnt canonical pathway in the process of DN, we uncovered evidence supporting that both Wnt/PCP and Wnt/Ca2+ signaling are critical for DN development.

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“…Although neudesin was identified less than 20 years ago [ 164 ], it still remains mostly unexplored, and is only now becoming a subject of metabolism-related studies (in diseases, relating to obesity, diabetes mellitus, insulin resistance and PCOS) [ 34 , 167 , 168 , 169 , 170 , 171 , 172 ].…”

Section: Neudesinmentioning

confidence: 99%

Review of Novel Potential Insulin Resistance Biomarkers in PCOS Patients—The Debate Is Still Open

Kruszewska

Laudy-Wiaderny²,

Kunicki

2022

IJERPH

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Research on proteins and peptides that play roles in metabolic regulation, which may be considered potential insulin resistance markers in some medical conditions, such as diabetes mellitus, obesity and polycystic ovarian syndrome (PCOS), has recently gained in interest. PCOS is a common endocrine disorder associated with hyperandrogenemia and failure of ovulation, which is often accompanied by metabolic abnormalities, including obesity, dyslipidemia, hyperinsulinemia, and insulin resistance. In this review, we focus on less commonly known peptides/proteins and investigate their role as potential biomarkers for insulin resistance in females affected by PCOS. We summarize studies comparing the serum fasting concentration of particular agents in PCOS individuals and healthy controls. Based on our analysis, we propose that, in the majority of studies, the levels of nesfastin-1, myonectin, omentin, neudesin were decreased in PCOS patients, while the levels of the other considered agents (e.g., preptin, gremlin-1, neuregulin-4, xenopsin-related peptide, xenin-25, and galectin-3) were increased. However, there also exist studies presenting contrary results; in particular, most data existing for lipocalin-2 are inconsistent. Therefore, further research is required to confirm those hypotheses, as well as to elucidate the involvement of these factors in PCOS-related metabolic complications.

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The level of the neudesin in Type-2 Diabetic patients and the relationship between the metabolic parameters and carotid intima-media thickness

Cited by 8 publications

References 0 publications

Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children

Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children

The Wnt Signaling Pathway in Diabetic Nephropathy

Review of Novel Potential Insulin Resistance Biomarkers in PCOS Patients—The Debate Is Still Open

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