The level of vascular endothelial cell growth factor, nitric oxide, and endothelin-1 was correlated with ovarian volume or antral follicle counts: A potential predictor of pregnancy outcome in IVF

Zhao, Mengjie; Chang, Cai; Liu, Z; Chen, L M; Chen, Q

doi:10.3109/08977191003766866

Cited by 10 publications

(8 citation statements)

References 30 publications

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“…ET-1 also can induce expression of the TGF-β receptor 1 and 2 genes, suggesting an important role for ET-1 in the establishment and progression of tissue fibrosis. It has been reported[ 18 ] that the ovarian volume and antral follicle count are positively correlated with the concentration of VEGF and negatively correlated with the concentration of ET-1 in follicular fluid. However, there are few studies on ovarian fibrosis and VEGF or ET-1, but they are important cytokines in ovarian fibrosis and further research is necessary into their specific mechanisms and possible role in treatment.…”

Section: P Athogenetic M Echanism Of mentioning

confidence: 99%

Ovarian Fibrosis

Zhou

Shi

Zhang

2017

Chinese Medical Journal

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Objective:Ovarian fibrosis is characterized by excessive proliferation of ovarian fibroblasts and deposition of extracellular matrix (ECM) and it is one of the principal reasons for ovarian dysfunction. This review aimed to investigate the pathogenetic mechanism of ovarian fibrosis and to clarify the relationship between ovarian diseases and fibrosis.Data Sources:We searched PubMed for English language articles published up to November 2016. The search terms included ovarian fibrosis OR fibrosis, ovarian chocolate cyst OR ovarian endometrioma, polycystic ovarian syndrome (PCOS), premature ovarian failure, ECM, matrix metalloproteinases (MMPs), tissue inhibitors of matrix metalloproteinases (TIMPs), transforming growth factor-beta 1 (TGF-β1), connective tissue growth factor (CTGF), peroxisome proliferator-activated receptor gamma (PPAR-γ), vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), and combinations of these terms.Study Selection:Articles were obtained and reviewed to analyze the pathogenic mechanism of ovarian fibrosis and related ovarian diseases.Results:Many cytokines, such as MMPs, TIMPs, TGF-β1, CTGF, PPAR-γ, VEGF, and ET-1, are involved in ovarian fibrogenesis. Ovarian fibrogenesis is associated with various ovarian diseases, including ovarian chocolate cyst, PCOS, and premature ovarian failure. One finding of particular interest is that fibrogenesis in peripheral tissues around an ovarian chocolate cyst commonly causes ovarian function diminution, and therefore, this medical problem should arouse widespread concern in clinicians worldwide.Conclusions:Patients with ovarian fibrosis are susceptible to infertility and tend to have decreased responses to assisted fertility treatment. Thus, protection of ovarian function should be a priority for women who wish to reproduce when making therapeutic decisions about ovarian fibrosis-related diseases.

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Section: P Athogenetic M Echanism Of mentioning

confidence: 99%

Ovarian Fibrosis

Zhou

Shi

Zhang

2017

Chinese Medical Journal

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“…Interestingly, HABP2 is one of the few genes identified in a number of studies in receptive endometrium (24, 45, 53). Vascular endothelial growth factor A synthesis by blastocysts has been demonstrated (61,62), and its expression level in follicular fluid has been correlated with pregnancy outcome in in vitro fertilization (IVF) treatment (63). Integrins are expressed by both blastocyst-derived trophoblast cells and endometrial epithelial cells and are intimately involved in mediating embryo adhesion (59,60,64).…”

Section: Embryo-endometrium Interaction Networkmentioning

confidence: 99%

Research Resource: Interactome of Human Embryo Implantation: Identification of Gene Expression Pathways, Regulation, and Integrated Regulatory Networks

Altmäe

Reimand

Hovatta

et al. 2012

Molecular Endocrinology

103

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A prerequisite for successful embryo implantation is adequate preparation of receptive endometrium and the establishment and maintenance of a viable embryo. The success of implantation further relies upon a two-way dialogue between the embryo and uterus. However, molecular bases of these preimplantation and implantation processes in humans are not well known. We performed genome expression analyses of human embryos (n = 128) and human endometria (n = 8). We integrated these data with protein-protein interactions in order to identify molecular networks within the endometrium and the embryo, and potential embryo-endometrium interactions at the time of implantation. For that, we applied a novel network profiling algorithm HyperModules, which combines topological module identification and functional enrichment analysis. We found a major wave of transcriptional down-regulation in preimplantation embryos. In receptive-stage endometrium, several genes and signaling pathways were identified, including JAK-STAT signaling and inflammatory pathways. The main curated embryo-endometrium interaction network highlighted the importance of cell adhesion molecules in the implantation process. We also identified cytokine-cytokine receptor interactions involved in implantation, where osteopontin (SPP1), leukemia inhibitory factor (LIF) and leptin (LEP) pathways were intertwining. Further, we identified a number of novel players in human embryo-endometrium interactions, such as apolipoprotein D (APOD), endothelin 1 (END1), fibroblast growth factor 7 (FGF7), gastrin (GAST), kringle containing trnasmembrane protein 1 (KREMEN1), neuropilin 1 (NRP1), serpin peptidase inhibitor clade A member 3 (SERPINA3), versican (VCAN), and others. Our findings provide a fundamental resource for better understanding of the genetic network that leads to successful embryo implantation. We demonstrate the first systems biology approach into the complex molecular network of the implantation process in humans.

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“…It plays an important role in regulating reproductive hormone secretion, animal reproductive function, muscle contraction, and cell mitosis. Zhao believes that ET-mediated local vascular regulation disorders and microcirculation disturbances may affect physiological reproductive organ functions [21].…”

Section: Introductionmentioning

confidence: 99%

Effect of cold stress on ovarian & uterine microcirculation in rats and the role of endothelin system

Wang

Xiao

Fang

et al. 2020

Reprod Biol Endocrinol

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Background: Cold, an environmental factor, induces many reproductive diseases. It is known that endothelin (ET) is a potent vasoconstrictor, and cold stress can increase the expression of ET and its receptors. The cold stress rat model was developed to examine two parameters: (1) the effects of cold stress on ovarian and uterine morphology, function, and microvascular circulation and (2) possible mechanisms of ET and its receptors involved in cold stress-induced menstruation disorders. Methods: The rat cold stress model was prepared with an ice water bath. The estrous cycle was observed by methylene blue and hematoxylin and eosin (H&E) staining. Serum estradiol 2 (E 2), testosterone (T), progesterone (P) were detected by radioimmunoassay. Hemorheology indices were measured. The real-time blood flow of auricle and uterine surfaces was measured. Expressions of CD34 and α-SMA in ovarian and uterine tissues were detected by immunohistochemistry. ET-1 contents in serum were tested, and expressions of ET-receptor types A and B (ET-AR and ET-BR) in ovarian tissues were detected via Western blotting. Results: Cold stress extended the estrous cycle, thereby causing reproductive hormone disorder, imbalance of local endothelin/nitric oxide expression, and microcirculation disturbance. Cold-stress led to up-regulation of ET-AR expression and protein and down-regulation of ET-BR expression in rats. Conclusions: This study suggests that the reason for cold stress-induced dysfunction in reproductive organs may be closely related to the imbalance of ET-1 and its receptor expressions, leading to microvascular circulation disorders in local tissues.

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The level of vascular endothelial cell growth factor, nitric oxide, and endothelin-1 was correlated with ovarian volume or antral follicle counts: A potential predictor of pregnancy outcome in IVF

Cited by 10 publications

References 30 publications

Ovarian Fibrosis

Ovarian Fibrosis

Research Resource: Interactome of Human Embryo Implantation: Identification of Gene Expression Pathways, Regulation, and Integrated Regulatory Networks

Effect of cold stress on ovarian & uterine microcirculation in rats and the role of endothelin system

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